DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and abcb8

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_001017544.1	Gene:	abcb8 / 548340	ZFINID:	ZDB-GENE-050410-6	Length:	714	Species:	Danio rerio

Alignment Length:	737	Identity:	256/737 - (34%)
Similarity:	394/737 - (53%)	Gaps:	90/737 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CTRLTHLCTTLRVRKSSQIRLSTSYNHHLGRCLHHRTARSL-QHSLPPPNRYHSHLHP------- 61
            |:|||....|       ..||.:|          |:|...| ||.    ||..:|..|
Zfish     7 CSRLTRGTVT-------SDRLLSS----------HKTRDFLFQHL----NRRGNHSAPWSSSQIP 50

  Fly    62 ----TLRMPWWCMRRGFAQSSKWL----------------------ARNAKANL--PTA-----V 93
                |:.:|   :.|.:.|:.|.|                      |....|.|  |:|     |
Zfish    51 STQLTVGVP---VLRIWRQAQKLLRLTSRQQPRPPSIALKFILGPAALTVTARLLGPSAHCEADV 112

  Fly    94 GAGIVPAPV----KMGRSQYGRLLSLTKSEKWVLTAGIGCLVVSSAITMSVPLFLGKVIDVVFNK 154
            ....||..|    |:....:..|....:.:.:.|...|.....::|:.:.:||.||.:::||...
Zfish   113 NNNKVPLEVQVKEKIPEFSWAVLWEFVRPQLFALMGAILLAFGAAALNIQIPLMLGDLVNVVARH 177

  Fly   155 SGMDSAAMAKLGEY-------SVLLFGIFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQ 212
                  ...:.|.|       :|.|.|::.|.|......:.|......|:...:|:.|:.|:|.|
Zfish   178 ------MREQAGHYMRDIQAPAVKLLGLYALQGLLTSGYIILLSRVGERVAADMRTTLFTSLLRQ 236

  Fly   213 EVGWFDTKGTGELINRLSNDTLMVGTSLSQNVSDGLRSVAMIGVGTGMMIY-TSPQLAAVSALVV 276
            ::.:||...||:|:|||::|.....:|....:|.||||.... ||..:.:| .||:|..::.:|:
Zfish   237 DIAFFDANKTGQLVNRLTSDIQEFKSSFKLVISQGLRSATQT-VGCFVSLYFISPKLTGLTVVVL 300

  Fly   277 PAMAGMAIVYGRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQI 341
            |.:.|...:.|.::|::::...::.|:....|:|..|||:||:.|..|.:|:..:..::.::..:
Zfish   301 PCLVGAGALIGSFLRKLSRKAQEQVAKATGVADEALGNVRTVRAFAMEDRELEMYAAEVQKSAAM 365

  Fly   342 GYKETRARAIFFGLTGFCGNFIIISVLYYGGTLVLQDSLTIGALTAFMLYAGYVAISMNGLSNFY 406
            ........|:|.||:....|.|::..::.||:|:.:|.|:.|.|.:|::.:..|..|:..:|..:
Zfish   366 NETLGTGIAVFQGLSNIVLNCIVLGTIFAGGSLMARDDLSPGDLMSFLVASQTVQRSLASISILF 430

  Fly   407 SQLNKGIGASERIWEILDRECSIPI-DKGVVPLEKPVGEVGFQNVFFTFPTRPESAVLTDFSLNL 470
            .|:.:|:.|..|::|.|..:.|:|: ..|.:||:..:|.|.|.|:.|::||||.:.:|..|||.|
Zfish   431 GQMVRGMSAGARVFEYLALDPSVPLTGGGRIPLDSLMGRVDFMNISFSYPTRPGNQILKHFSLTL 495

  Fly   471 MPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNN-IGAVSQEPVLFS 534
            .|..|.|:||.||.||:|:|.|:.|.|||..|.|.|||:|:||::|.|||.: ||.:|||||||.
Zfish   496 PPCKTVAIVGESGGGKSTVAALLERFYDPSSGVVMLDGLDIRTLDPSWLRGHVIGFISQEPVLFG 560

  Fly   535 CSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAIAR 599
            .|:.|||.:| .|..|.:  .:....:.||...|.....||.:|:||:||:.||||||||:||||
Zfish   561 TSVMENIRFG-KPSATDA--EVVSAAKQANAHNFITGFADGYNTVVGERGVTLSGGQKQRIAIAR 622

  Fly   600 ALIKNPAILILDEATSALDAVSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKIVE 664
            ||:|||:|||||||||||||.||.:||.|||....|||||.||||||||:.||.|.|:|:|:|||
Zfish   623 ALVKNPSILILDEATSALDAESERVVQEALDRATTGRTVLIIAHRLSTIQAADLICVMSNGRIVE 687

  Fly   665 QGSYNELMGIQEGVFRELVASQ 686
            .|::.||:. :.|::.||:..|
Zfish   688 AGTHLELLS-KGGLYAELIKRQ 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	223/591 (38%)
		ABC_membrane	127..395	CDD:279056	73/275 (27%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	131/239 (55%)
abcb8	NP_001017544.1	ABC_6TM_ABCB8_like	149..443	CDD:350018	79/300 (26%)
		TM helix 1	149..172	CDD:350018	6/22 (27%)
		TM helix 2	187..236	CDD:350018	11/48 (23%)
		TM helix 3	243..288	CDD:350018	16/45 (36%)
		TM helix 4	289..338	CDD:350018	11/48 (23%)
		TM helix 5	350..396	CDD:350018	7/45 (16%)
		TM helix 6	409..442	CDD:350018	8/32 (25%)
		ABC_MTABC3_MDL1_MDL2	470..708	CDD:213216	132/241 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D221577at33208
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.730