Protein Alignment CG3156 and ABCB4

DIOPT Version :9

• Sequence 1: NP_569844.2
• Gene: CG3156 / 30994
• FlyBaseID: FBgn0023536
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: XP_011514610.3
• Gene: ABCB4 / 5244
• HGNCID: 45
• Length: 1384
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 224/614 - (36%)
• Similarity: 333/614 - (54%)
• Gaps: 57/614 - (9%)

  Fly    92 AVGAGIVPAPVKMGRSQYGRLLSLTKSEKWVLTAGIGCLVVSSAITMSVPLFLGKVIDVVFNKSG 156
            |.|:|:   |:.|  ..:|.:     ::|:|.|||.....|:.::::..|   ||:::....:..
Human   156 AHGSGL---PLMM--IVFGEM-----TDKFVDTAGNFSFPVNFSLSLLNP---GKILEEEMTRYA 207

  Fly   157 MDSAAMAKLGEYSVLLFGIFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFDTKG 221
            .         .||.|..|:.|    |.:.:|..:..||.|.:|.:|.:.:.::|.||:||||...
Human   208 Y---------YYSGLGAGVLV----AAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDIND 259

  Fly   222 TGELINRLSNDTLMVGTSLSQNVSDGLRSVAMIGVGTGMMIYTSPQLAAVSALVVPAMAGMAIVY 286
            |.||..||::|...:...:...|....::||....|..:......:|..|...:.|.:...|.|:
Human   260 TTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVW 324

  Fly   287 GRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGYKETRARAI 351
            .:.:...:..||..||:....|||..|.::||..|..:.:|:..:...|:.|.:||.|:..:..|
Human   325 AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANI 389

  Fly   352 FFGLTGFCGNFIIISVLY-----YGGTLVLQDSLTIG-ALTAFM------LYAGYVAISMNGLSN 404
            ..|:.     |::|...|     ||.|||:....||| |:|.|.      ...|..|..::..:|
Human   390 SMGIA-----FLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFAN 449

  Fly   405 FYSQLNKGIGASERIWEILDRECSIP--IDKGVVPLEKPVGEVGFQNVFFTFPTRPESAVLTDFS 467
                   ..||:..|::|:|....|.  .::|..| :...|.:.|.:|.|::|:|....:|...:
Human   450 -------ARGAAYVIFDIIDNNPKIDSFSERGHKP-DSIKGNLEFNDVHFSYPSRANVKILKGLN 506

  Fly   468 LNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNNIGAVSQEPVL 532
            |.:..|.|.|:||.||.||:|...|:.|||||..||:::||.|:|..|..:||..||.|||||||
Human   507 LKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVL 571

  Fly   533 FSCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAI 597
            ||.:|.|||.||..   ..:.:.:::.:::||..:|..:||...|||||:||..||||||||:||
Human   572 FSTTIAENICYGRG---NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAI 633

  Fly   598 ARALIKNPAILILDEATSALDAVSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKI 662
            ||||::||.||:|||||||||..||..||.|||...:|||.:.|||||||:||||.||...||.|
Human   634 ARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVI 698

  Fly   663 VEQGSYNELMGIQEGVFRELVASQAFGSR 691
            |||||::|||. :|||:.:||..|..||:
Human   699 VEQGSHSELMK-KEGVYFKLVNMQTSGSQ 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	216/594 (36%)
		ABC_membrane	127..395	CDD:279056	72/279 (26%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	127/238 (53%)
ABCB4	XP_011514610.3	AAA	108..1369	CDD:333001	224/614 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810