DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and ABCB5

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_001157413.1	Gene:	ABCB5 / 340273	HGNCID:	46	Length:	1257	Species:	Homo sapiens

Alignment Length:	633	Identity:	207/633 - (32%)
Similarity:	331/633 - (52%)	Gaps:	42/633 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RRGFAQSSKWLARNAKANLPTAVGAGIVPAPVKMGRSQYGRLLSLTKSEKWVLTAGIGCLVVSSA 135
            |.|.|:....|.:.       |||:      :::.|...|  |.:|     ::..||...:|:.|
Human    16 RNGTAEEQPKLRKE-------AVGS------IEIFRFADG--LDIT-----LMILGILASLVNGA 60

  Fly   136 ITMSVPLFLGKVID-------VVFNKSGMDSAAMA--KLGEYSVLL----FGIFVLGGFANFARV 187
            ....:||.||::.|       |..|.:...:...:  ||.|...||    .||.|......:.::
Human    61 CLPLMPLVLGEMSDNLISGCLVQTNTTNYQNCTQSQEKLNEDMTLLTLYYVGIGVAALIFGYIQI 125

  Fly   188 HLFGNAALRIVRSLRSRLYRSMLMQEVGWFDTKGTGELINRLSNDTLMVGTSLSQNVSDGLRSVA 252
            .|:...|.|..:.:|.:.:.|:|.|::||||:...|||..|:::|...:...:...::...::::
Human   126 SLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGDKIALLFQNMS 190

  Fly   253 MIGVGTGMMIYTSPQLAAVSALVVPAMAGMAIVYGRYVRRITKVELDKYAEIMKFAEERFGNVKT 317
            ...:|..:.:....:|..|:....|.:...|....|.|..:|..||..|::....|||...:::|
Human   191 TFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVISLTSKELSAYSKAGAVAEEVLSSIRT 255

  Fly   318 VKTFCREQQEVAAFDGKLDEALQIGYKETRARAIFFGLTGFCGNFIIISVLYYGGTLVL--QDSL 380
            |..|..:::|:..:...|.:|...|.|.|.|..:..|...|..|.......:||.:|:|  :...
Human   256 VIAFRAQEKELQRYTQNLKDAKDFGIKRTIASKVSLGAVYFFMNGTYGLAFWYGTSLILNGEPGY 320

  Fly   381 TIGALTAFMLYAGYVAISMNGLSNFYSQLNKGIGASERIWEILDRECSIP--IDKGVVPLEKPVG 443
            |||.:.|......:.:..:......:.......||:..|::::|::.||.  ...|..| |...|
Human   321 TIGTVLAVFFSVIHSSYCIGAAVPHFETFAIARGAAFHIFQVIDKKPSIDNFSTAGYKP-ESIEG 384

  Fly   444 EVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDG 508
            .|.|:||.|.:|:||...:|...:|.:..|.|.|:||.:||||:|:..|:.|||||..|.:.:|.
Human   385 TVEFKNVSFNYPSRPSIKILKGLNLRIKSGETVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDE 449

  Fly   509 IDLRTVNPQWLRNNIGAVSQEPVLFSCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLP 573
            .|:|.:|.:..|::||.||||||||..:|..||.||.   :..:.|.:::...:||...|..:.|
Human   450 NDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGR---DDVTDEEMERAAREANAYDFIMEFP 511

  Fly   574 DGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSALDAVSENLVQNALDNLIQGRTV 638
            :..:||||::|..:|||||||:||||||::||.||||||||||||:.|::.||.||:...:|||.
Human   512 NKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTT 576

  Fly   639 LTIAHRLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFRELVASQ 686
            :.:||||||||:||.|..|.||.:.|:|::.|||. :.|::..||.||
Human   577 IVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMA-KRGLYYSLVMSQ 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	200/598 (33%)
		ABC_membrane	127..395	CDD:279056	69/282 (24%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	113/238 (47%)
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		3/7 (43%)
		PTZ00265	8..1251	CDD:240339	207/633 (33%)
		ABC_membrane	52..333	CDD:279056	69/280 (25%)
		ABC_MTABC3_MDL1_MDL2	386..623	CDD:213216	114/240 (48%)
		ABC_membrane	696..962	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1016..1254	CDD:213216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810