DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and CG1824

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_572810.1	Gene:	CG1824 / 32208	FlyBaseID:	FBgn0030403	Length:	761	Species:	Drosophila melanogaster

Alignment Length:	719	Identity:	256/719 - (35%)
Similarity:	382/719 - (53%)	Gaps:	67/719 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LRVRKSSQIRLSTSYNHHL--------------GRCL--HHRTARSLQ-HSLPPPNRYHSHLHPT 62
            ||:..|:..|.|..::.||              .|.:  |.|...:.| .::||.|.  |.|..|
  Fly     2 LRLLVSNCGRSSDIFSRHLLQPTQQPLPRLQNAARLMRQHLRGTNAPQPPAIPPTNA--SRLLQT 64

  Fly    63 LRM---------------PWWCMRRG---FAQSSKWLARNAKANLPTAVGAGIVPAPVKMGRSQY 109
            .|:               .||...||   ..:.|:...|..:....||          ......:
  Fly    65 TRLLVWGGGSLAIGLGARSWWAGHRGAIVHCEGSRLAIRKEEEEEDTA----------SEQHFDW 119

  Fly   110 GRLLSLTKSEKWVLTAGIGCLVVSSAITMSVPLFLGKVIDVV---FNKSGMD---SAAMAKLGEY 168
            .||.:..:...|.|...:...::.:.|.:.:|..||.:::.:   .|...||   ::.:..:.:.
  Fly   120 KRLWTYLEPHLWELIGAVCAALIVAYINIRIPNLLGDLVNTLARYANTYVMDPINNSFVKDVSKP 184

  Fly   169 SVLLFGIFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFDTKGTGELINRLSNDT 233
            :..|..:::|.....|..::|......::...:|..|:..:::|::.:||...||||:|||:.|.
  Fly   185 ASNLLSLYMLQSGFTFMYIYLLSRVGEQMAAKMRQDLFTQIVVQDIAFFDENRTGELVNRLTADV 249

  Fly   234 LMVGTSLSQNVSDGLRSVAMIGVGTGMMIYTSPQLAAVSALVVPAMAGMAIVYGRYVRRITKVEL 298
            ....||..|.||.||||.|.:..|:..:...||.:||::...||.:.......|:.:|.::|...
  Fly   250 QDFKTSFKQFVSQGLRSAAQLIGGSISLFMISPHMAAIALASVPCVVMFMTYLGKKLRSLSKSSQ 314

  Fly   299 DKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGYKETRARAIFFGLTGFCGNFI 363
            .:........||...|::||::...|.:|:..|:.:.:||.::..|.....|||.|||.|..|.:
  Fly   315 AQAERATGVCEEALSNIRTVRSSACEYREMQLFEAETNEAARLAQKLGYGIAIFQGLTNFFLNTL 379

  Fly   364 IISVLYYGGTLVLQDSLTIGALTAFMLYAGYVAISMNGLSNFYSQLNKGIGASERIWEILDRECS 428
            ::|.|:.||.|:..:||:.|||.||::.:..|..|:...|.....:.:|:.|..|::|.|..:..
  Fly   380 VLSTLFMGGHLMSTESLSPGALMAFLVASQGVQRSLAQGSILLGTMIRGMSAGSRVFEFLSLQPQ 444

  Fly   429 IPIDKG-VVPLEKPVGEVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIALL 492
            :.:.:| ::|.|:..||:.|:||.|.:|.:|:..||.||||.|.||.|.|:||.|||||:|||.|
  Fly   445 VELLRGYIIPQERLHGEIRFENVSFAYPMQPDHLVLKDFSLTLRPGQTVALVGASGSGKSTIASL 509

  Fly   493 MLRLYDPQGGTVHLDGIDLRTVNPQWLRNNI-GAVSQEPVLFSCSIRENILYG-ANPGETPSPER 555
            :.|.|:|..|.:.|||..|..::|.|||:|: |.:.|:||||..||.|||.|| .:.||
  Fly   510 VERFYEPSAGNIKLDGYKLSDISPYWLRSNVLGFIEQQPVLFGTSILENIRYGKPDAGE------ 568

  Fly   556 LQQVIEDANVSQ---FTDQLPDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSAL 617
             :.|...|.:||   |...||||..|.||:||..|||||:||:||||||:|||.|||||||||||
  Fly   569 -EDVYAAARLSQSHDFVTALPDGYATHVGERGTQLSGGQRQRIAIARALLKNPRILILDEATSAL 632

  Fly   618 DAVSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFREL 682
            ||.||..||.|||.::|.||.|.||||||||||||.|.||..|::||.|.::|||| :.|::.||
  Fly   633 DATSEAEVQKALDTVVQNRTTLVIAHRLSTIRNADLIVVLDQGRVVETGKHDELMG-KRGLYFEL 696

  Fly   683 VASQ 686
            |..|
  Fly   697 VRQQ 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	230/593 (39%)
		ABC_membrane	127..395	CDD:279056	75/273 (27%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	137/243 (56%)
CG1824	NP_572810.1	MdlB	119..701	CDD:224055	230/590 (39%)
		ABC_membrane	137..415	CDD:279056	76/277 (27%)
		ABC_MTABC3_MDL1_MDL2	462..700	CDD:213216	137/245 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I220
eggNOG	1	0.900	-	-		E2759_KOG0058
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I92
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221577at33208
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	1	1.000	-	-		otm51436
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	P	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.870