DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and Tap2

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_035660.3	Gene:	Tap2 / 21355	MGIID:	98484	Length:	702	Species:	Mus musculus

Alignment Length:	619	Identity:	213/619 - (34%)
Similarity:	332/619 - (53%)	Gaps:	30/619 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SSKW---LARNAKANLPTAVGAGIVPA------PVKMGRSQYGRLLSLTKSEKWVLTAGIGCLVV 132
            |:.|   ||......|..||.|.:.||      |.:..|:...|||.|::.:...|.|....|||
Mouse    96 SASWGWLLAGYGAVALSWAVWAVLSPAGVQEKEPGQENRTLMKRLLKLSRPDLPFLIAAFFFLVV 160

  Fly   133 SSAITMSVPLFLGKVIDVVFNKSGMDSAAMAKLGEYSVLLFGIFVLG-GFANFARVHLFGNAALR 196
            :......:|.:.|:|||::......|:.|.|      :....:|.:| .|:...|...|.....|
Mouse   161 AVWGETLIPRYSGRVIDILGGDFDPDAFASA------IFFMCLFSVGSSFSAGCRGGSFLFTMSR 219

  Fly   197 IVRSLRSRLYRSMLMQEVGWFDTKGTGELINRLSNDTLMVGTSLSQNVSDGLRS-VAMIGVGTGM 260
            |...:|.:|:.|:|.|::|:|....||||.:|||:||.::...|..|.:..||| |.::|: ...
Mouse   220 INLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGL-YFF 283

  Fly   261 MIYTSPQLAAVSALVVPAMAGMAIVYGRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQ 325
            |:..||:|..:|.|.:|.......||....:.:.|...|..|:..:...|..|.::||::|..|:
Mouse   284 MLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEE 348

  Fly   326 QEVAAFDGKLDEALQIGYKETRARAIFFGLTGFCGNFIIISVLYYGGTLVLQDSLTIGALTAFML 390
            |||:.:...|:...|:.::....:.::..:.......:.:.:|..|...:|...:|.|.|.:|:|
Mouse   349 QEVSHYKEALERCRQLWWRRDLEKDVYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLL 413

  Fly   391 YAGYVAISMNGLSNFYSQLNKGIGASERIWEILDRECSIPIDKGVVPLEKPVGEVGFQNVFFTFP 455
            |...|...:..|...|..:...:||:|:::..|||:.::| ..|::......|.|.||:|.|::|
Mouse   414 YQEEVGQYVRNLVYMYGDMLSNVGAAEKVFSYLDRKPNLP-QPGILAPPWLEGRVEFQDVSFSYP 477

  Fly   456 TRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLR 520
            .|||..||...:..|.|||.||:||.:||||:|:|.|:..||.|.||.:.|||..|...:..:|.
Mouse   478 RRPEKPVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLH 542

  Fly   521 NNIGAVSQEPVLFSCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDTLVGQRGM 585
            ..:..|.|||||||.|:::||.||....|   ..::....:.|....|..::.:|::|.:|::|.
Mouse   543 RQVVLVGQEPVLFSGSVKDNIAYGLRDCE---DAQVMAAAQAACADDFIGEMTNGINTEIGEKGG 604

  Fly   586 MLSGGQKQRVAIARALIKNPAILILDEATSALDAVSENLVQNALDNLIQG-RTVLTIAHRLSTIR 649
            .|:.|||||:||||||::||.:||||||||||||..|..:||...   || ||:|.|||||.|::
Mouse   605 QLAVGQKQRLAIARALVRNPRVLILDEATSALDAQCEQALQNWRS---QGDRTMLVIAHRLHTVQ 666

  Fly   650 NADQIAVLSDGKIVEQGSYNELMGIQEGVFRELV 683
            ||||:.||..|::||   :::|...|: |:..||
Mouse   667 NADQVLVLKQGRLVE---HDQLRDGQD-VYAHLV 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	202/581 (35%)
		ABC_membrane	127..395	CDD:279056	73/269 (27%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	109/238 (46%)
Tap2	NP_035660.3	3a01208	1..696	CDD:273363	211/617 (34%)
		ABC_membrane	155..415	CDD:279056	72/266 (27%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03519	300..388		17/87 (20%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03519	413..432		5/18 (28%)
		P-loop_NTPase	456..679	CDD:304359	105/228 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820