DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and Abcb1b

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_035205.1	Gene:	Abcb1b / 18669	MGIID:	97568	Length:	1276	Species:	Mus musculus

Alignment Length:	655	Identity:	222/655 - (33%)
Similarity:	346/655 - (52%)	Gaps:	71/655 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 RGFAQSSKWLARNAKANLPTAVGAGIVPAPVKMGRSQYGRLLSLTKSEKWVLTAGIGCLVVSSAI 136
            :.|::..|...:..|...| |||.        .|..:|...|     :|..:..|....::...:
Mouse    13 KNFSKMGKKSKKEKKEKKP-AVGV--------FGMFRYADWL-----DKLCMILGTLAAIIHGTL 63

  Fly   137 TMSVPLFLGKVID-----------VVFNKSGMDSAAM---AKLGE--------YSVLLFGIFVLG 179
            ...:.|..|.:.|           .:.|:||.:|..:   :.|.|        |:.:..|:.::.
Mouse    64 LPLLMLVFGNMTDSFTKAEASILPSITNQSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVA 128

  Fly   180 GFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFDTKGTGELINRLSNDTLMVGTSLSQNV 244
                :.:|.|:..||.|.:..:|.:.:.:::.||:||||....|||..||::|...:...:...:
Mouse   129 ----YIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINDGIGDKI 189

  Fly   245 SDGLRSVAMIGVGTGMMIYTSPQLAAVSALVVPAMAGMAIVYGRYVRRITKVELDKYAEIMKFAE 309
            ....:|:.....|..:...:..:|..|...|.|.:...:.::.:.:...|..||..||:....||
Mouse   190 GMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAE 254

  Fly   310 ERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGYKETRARAIFFGLTGFCGNFIIISVLY----- 369
            |....::||..|..:|:|:..::..|:||..:|.|:....:|..|:.     ::::...|
Mouse   255 EVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIA-----YLLVYASYALAFW 314

  Fly   370 YGGTLVLQDSLTIG-ALTAFM------LYAGYVAISMNGLSNFYSQLNKGIGASERIWEILDREC 427
            ||.:|||.:..:|| .||.|.      ...|::|.::...:|       ..||:..|::|:|.|.
Mouse   315 YGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFAN-------ARGAAFEIFKIIDNEP 372

  Fly   428 SIP--IDKGVVPLEKPVGEVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIA 490
            ||.  ..||..| :..:|.:.|:||.|.:|:|.|..:|...:|.:..|.|.|:||.||.||:|..
Mouse   373 SIDSFSTKGYKP-DSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTV 436

  Fly   491 LLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNNIGAVSQEPVLFSCSIRENILYGANPGETPSPER 555
            .||.|||||..|.|.:||.|:||:|.::||..||.||||||||:.:|.|||.||.   |..:.:.
Mouse   437 QLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGR---EDVTMDE 498

  Fly   556 LQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSALDAV 620
            :::.:::||...|..:||...|||||:||..||||||||:||||||::||.||:|||||||||..
Mouse   499 IEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE 563

  Fly   621 SENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFRELVAS 685
            ||.:||.|||...:|||.:.|||||||:||||.||....|.|||||:::|||. ::|::.:||.:
Mouse   564 SEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMR-EKGIYFKLVMT 627

  Fly   686 QAFGS 690
            |..|:
Mouse   628 QTRGN 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	212/616 (34%)
		ABC_membrane	127..395	CDD:279056	67/301 (22%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	127/238 (53%)
Abcb1b	NP_035205.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		2/12 (17%)
		PTZ00265	55..1270	CDD:240339	210/599 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..659		222/655 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810