DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and pgp-10

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_509205.2	Gene:	pgp-10 / 180981	WormBaseID:	WBGene00004004	Length:	1382	Species:	Caenorhabditis elegans

Alignment Length:	634	Identity:	196/634 - (30%)
Similarity:	308/634 - (48%)	Gaps:	84/634 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 YGRLLSLTKS-EKWVLTAGIGCLVVSSAITMSVPLFLGKVIDV-VFNKSGMDSAAMAKLG----- 166
            |.||.:...| :..::..|:...::.||:...|.|.:|..:.: :..:.|       |||
Worm    82 YKRLYAFADSIDMQLMAMGLFSALLQSALPPFVWLIMGNFVSISILREEG-------KLGLKNLT 139

  Fly   167 -EYS-------------VLLFGIFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWF 217
             :|.             :.:.|:.:....|.|.:...:..:::|.|..::....|.:|:.::.|.
Worm   140 SDYPIDDQFAHSATPAFISMLGLSIAMFIAAFCQRIAWEISSIRQVFRIKKAYIRKLLLMDISWL 204

  Fly   218 DTKGTGELINRLSNDTLMVGTSLSQNVSDGLRSVAMI----GVGTGMMIYTSPQLAAVSALVVPA 278
            :::.:|.:...|...    ..|:...:||.|..|..|    .|..|:.:|....:.....|.:|.
Worm   205 ESRQSGHVAAMLQES----ADSIYNGISDHLPMVVFILSYLLVNIGVCLYIQWDVTLFMCLAIPL 265

  Fly   279 MAGMAIVYGRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGY 343
            :....|:|.::.....:.|.....:|.....|.|..:.||.:|..::|::..|:....|..::..
Worm   266 LIISRILYSKWFANTMEEETKLQNKITNLVNETFNCITTVISFAAQKQKINKFEKLSAEHSKLTE 330

  Fly   344 KETRARAIFFGLTG-FCGNFIIISVLYYGGTLVLQDSL-TIGALTAFMLYAGYVAIS----MNGL 402
            :..|:..:|..||. .....|....|.||...|..:|. .:.||...|||....:||    |||.
Worm   331 ERLRSSVVFDSLTQILLTELIFTGALCYGIWRVADNSPGRLCALAINMLYMCVTSISIGFHMNGA 395

  Fly   403 SNFYSQLNKGIGASERIWEILDRECSI-----PIDKGV--VPLEK-----------PVGEVGFQN 449
            :       :....::.|.|:|:.:..|     .||..:  ||:.:           ..|.:.|::
Worm   396 T-------RAKDNAKEICEVLNEQPKIEVELASIDNNIDYVPVTRCKYRRQSMKFMGKGALHFRD 453

  Fly   450 VFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTV 514
            :.|::|:|.|:.||...|..:..|...|:||.|||||:|:..|:||.|||..|.:.|||.:::|:
Worm   454 IHFSYPSRKETEVLRGISFKVEAGEKIAIVGSSGSGKSTLTALLLRFYDPTKGAILLDGENIKTM 518

  Fly   515 NPQWLRNNIGAVSQEPVLFSCSIRENILYGANPGETPSPERL---QQVIEDA----NVSQFTDQL 572
            .|..||.....||||||||..:|.:||.||          ||   ||.|.||    ...:|.:.|
Worm   519 CPDDLRGQCSLVSQEPVLFDGTISDNIRYG----------RLDATQQEINDAARKVGAWKFINSL 573

  Fly   573 PDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSALDAVSENLVQNALDNLIQGRT 637
            |||:.|.||:||..||||||||||||||:|:.|.:||.||||||||.:.|..|..|:|...:|.|
Worm   574 PDGMQTRVGERGHQLSGGQKQRVAIARAVIRKPIVLIFDEATSALDNIHEEEVNAAIDLASEGLT 638

  Fly   638 VLTIAHRLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFRELVASQ 686
            .:|||||||||:|:|:|.||.:|||||:|..:||:....|:|.::...|
Worm   639 TITIAHRLSTIKNSDRIIVLHEGKIVEEGVPDELIADANGIFHKMYNDQ 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	196/634 (31%)
		ABC_membrane	127..395	CDD:279056	58/293 (20%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	118/245 (48%)
pgp-10	NP_509205.2	MdlB	73..687	CDD:224055	195/632 (31%)
		ABC_membrane	156..381	CDD:294371	47/228 (21%)
		ABC_MTABC3_MDL1_MDL2	450..687	CDD:213216	118/246 (48%)
		ABC_membrane	823..1099	CDD:294371
		MdlB	825..1382	CDD:224055
		P-loop_NTPase	1141..1381	CDD:304359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010