DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3156 and pgp-9

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_507487.1	Gene:	pgp-9 / 180165	WormBaseID:	WBGene00004003	Length:	1294	Species:	Caenorhabditis elegans

Alignment Length:	655	Identity:	219/655 - (33%)
Similarity:	337/655 - (51%)	Gaps:	58/655 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 RRGFAQSSKWLARNAKANLPTAVG-----AGIVPAP---------VKMGRSQYG-------RLLS 114
            ||...|:|:   |....|..|...     .|..|||         :|....:.|       ::|.
Worm   636 RRMSRQTSQ---RKGSVNFKTQESQVDEKPGAPPAPEAAEKEIKRLKKELEEEGAVKANLFKILR 697

  Fly   115 LTKSEKWV-LTAGIGCLVVSSAITMSVPLFLGKVIDVVFNKSGMDSAAMAKLGEYSVLLFGIF-V 177
            ..:.| |: :...|...::..|:..:..||..::|:|..|.   |...|.|.|.:..|:|.:. .
Worm   698 YARPE-WIYIFFAIIAALIQGAVMPAFSLFFSQIINVFSNP---DRDQMKKDGHFWALMFLVLAA 758

  Fly   178 LGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFD--TKGTGELINRLSNDTLMVGTSL 240
            :.|.:...:..|||.||.|:...:||::||::|.|:..:||  ....|.:..||:.|...:.:::
Worm   759 VQGTSMLFQCSLFGVAAERLTMRIRSKVYRNVLRQDATYFDMPKHSPGRITTRLATDAPNIKSAI 823

  Fly   241 SQNVSDGLRSVAMIGVGTGMMIYTSPQLAAVSALVVPAMA-GMAIVYGRYVRRITKVELDKYAEI 304
            ...:.....::|.:|.|.|:..|...|:|.:...:.|.|| |.|::. :|.......:..:....
Worm   824 DYRLGSIFNAIASVGGGLGIAFYYGWQMAFLVMAIFPFMAVGQALMM-KYHGGSATSDAKEMENA 887

  Fly   305 MKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGYKETRARAIFFGLT-GFCGN---FIII 365
            .|.|.|...|::||:....:.:....|...||..    :....::||..||| ||..:   |...
Worm   888 GKTAMEAIENIRTVQALTLQTKLYNIFCSHLDAP----HGGNISKAIIRGLTYGFANSIQFFTYA 948

  Fly   366 SVLYYGGTLVLQDSL------TIGALTAFMLYAGYVAISMNGLSNFYSQLNKGIGASERIWEILD 424
            :...:|..|:...::      .:..|.|.....|.:..:    ::::.:..|...|:..|:.:|:
Worm   949 AAFRFGLFLIFDKNVLMEPENVLRVLFAISFSFGTIGFA----ASYFPEYIKATFAAGLIFNMLE 1009

  Fly   425 RECSIP--IDKGVVPLEKPVGEVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKT 487
            .|..|.  ...|..|  :..|||....|||.:|.||...:|...::::.||.|.|:||.||.||:
Worm  1010 EEPRIDGMTSSGTYP--QLSGEVKLNKVFFRYPERPAVPILQGLNVHVKPGQTLALVGPSGCGKS 1072

  Fly   488 TIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNNIGAVSQEPVLFSCSIRENILYGANPGETPS 552
            |:..|:.|||||..|.|.:|..|||.:||:.||.:|..|||||:||..||||||:||..|||. :
Worm  1073 TVISLLERLYDPLEGAVTVDNNDLRQMNPKHLRKHIALVSQEPILFDTSIRENIVYGLQPGEY-T 1136

  Fly   553 PERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSAL 617
            .|:::.....||:.:|.|:||||.:|.||::|..||||||||:|||||||:||.||:||||||||
Worm  1137 HEQIETACSKANIHKFIDELPDGYETRVGEKGTQLSGGQKQRIAIARALIRNPKILLLDEATSAL 1201

  Fly   618 DAVSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFREL 682
            |..||..||.|||...:.||.:.:|||||||.||..|.|:.:|::||||::|||:. :.|.:..|
Worm  1202 DTESEKQVQVALDAAAKDRTCIVVAHRLSTIVNAGCIMVVKNGQVVEQGTHNELIA-KRGAYFAL 1265

  Fly   683 VASQA 687
            ...|:
Worm  1266 TQKQS 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	206/604 (34%)
		ABC_membrane	127..395	CDD:279056	67/281 (24%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	124/238 (52%)
pgp-9	NP_507487.1	PTZ00265	28..1262	CDD:240339	217/645 (34%)
		ABC_membrane	50..334	CDD:279056
		ABC_MTABC3_MDL1_MDL2	383..620	CDD:213216
		ABC_membrane	710..977	CDD:279056	65/274 (24%)
		ABC_MTABC3_MDL1_MDL2	1030..1269	CDD:213216	125/240 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162804
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840