DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3156 and haf-2

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_495537.2	Gene:	haf-2 / 174204	WormBaseID:	WBGene00001812	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	670	Identity:	215/670 - (32%)
Similarity:	352/670 - (52%)	Gaps:	72/670 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 WCMRRGFAQSSKW-------------LARNAKANLPTAV-------------------GAGIVP- 99
            |.:..||.|...|             |......|..|:|                   |:...|
Worm   126 WSILSGFIQVLVWYFVFTSNPFDYHRLLNTTAENAGTSVTETAAETVRDTETASNVESGSSTAPR 190

  Fly   100 APVKMGRSQYGRLLSLTKSEKWV-LTAGIGCLVVSSAITMSVPLFLGKVIDVVFNKSGMDSAAMA 163
            ||:   .....||||.. ..:|. ..:|...|.|.:...:.:|.:..:||..:.||.|:.:
Worm   191 APL---HKVLLRLLSYC-GHQWPWFASGFVFLTVYALARVFIPNYTAQVISDIVNKRGIQA---- 247

  Fly   164 KLGEYSVLLFGIFVL----------GGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFD 218
                   |:..|.||          ||.    |...|..|...:...:|..|:.|::.|::.::|
Worm   248 -------LIHSIIVLTCLTATSSLFGGL----RGGCFDYATALVTLRIRLDLFTSLIRQDIAFYD 301

  Fly   219 TKGTGELINRLSNDTLMVGTSLSQNVSDGLRSVAMIGVGTGMMIYTSPQLAAVSALVVPAMAGMA 283
            |..||:.::||::|...:.:::|.||:..:|:..|:......||..|.:||.|:.:.||.:..:.
Worm   302 TAKTGDTMSRLTSDCQTISSTVSTNVNVFMRNGVMLIGALAFMILMSWRLAMVTFIAVPLVGFIT 366

  Fly   284 IVYGRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGYKETRA 348
            ..|..:..:|::......||..:.|||....::||::|..|::|:..|:.:|...|.:..|::.|
Worm   367 KAYSSFYDKISEKLQQTIAETNQMAEEVVSTMRTVRSFACEKKELKRFEDRLSSTLSVNRKKSIA 431

  Fly   349 RAIFFGLTGFCGNFIIISVLYYGGTLVLQDSLTIGALTAFMLYAGYVAISMNGLSNFYSQLNKGI 413
            ...:.....||.|.|:::||:|||.||:...:....|..|:||...:..::..||...|.|.:.:
Worm   432 YLFYTWNNEFCDNAILVAVLFYGGHLVMTGKMEKEQLITFLLYQMQLGENLYYLSYVMSGLMEAV 496

  Fly   414 GASERIWEILDRECSIPIDKGVVPLEKPV--GEVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTT 476
            |||.:::::::|:....:|    .:::|.  |.:.|.:|.||:|:||.:.||.|.:|::..|.|.
Worm   497 GASRKVFDLMNRKPQFELD----GMQRPFVNGNITFSHVGFTYPSRPNNPVLKDLTLSIKSGETV 557

  Fly   477 AVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNNIGAVSQEPVLFSCSIRENI 541
            |:||.||.||::|..|:...|:|..|:|.|||:.::.:|..:....:..|:|||||::.|:|.||
Worm   558 ALVGPSGGGKSSIVSLIEHFYEPDEGSVTLDGVPIKDINHVYYHQKVALVAQEPVLYNGSVRHNI 622

  Fly   542 LYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPA 606
            |||.   :..:.:.:....:.|||..|..:|..|.||..|::|:.:|||||||:||||||::|||
Worm   623 LYGC---DFATEDDMLNASKMANVHDFVMELEKGYDTNCGEKGVQMSGGQKQRIAIARALVRNPA 684

  Fly   607 ILILDEATSALDAVSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKIVEQGSYNEL 671
            :|||||||||||..||.|||.||....|.|||:.:|||||||..|::|||:..|.:|:.|::.||
Worm   685 VLILDEATSALDTESEALVQQALSRCAQERTVIIVAHRLSTIEKANKIAVIVKGCLVQMGTHTEL 749

  Fly   672 MGIQEGVFRELVASQAFGSR 691
            |...:|::..||:.|...::
Worm   750 MTDTDGMYYSLVSRQMLSAK 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	201/593 (34%)
		ABC_membrane	127..395	CDD:279056	73/277 (26%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	111/238 (47%)
haf-2	NP_495537.2	3a01208	15..761	CDD:273363	212/660 (32%)
		ABC_membrane	215..478	CDD:279056	73/277 (26%)
		ABC_MTABC3_MDL1_MDL2	526..764	CDD:213216	111/240 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I8332
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D684058at2759
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730