DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3156 and Abcc2

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_038834.2	Gene:	Abcc2 / 12780	MGIID:	1352447	Length:	1543	Species:	Mus musculus

Alignment Length:	684	Identity:	187/684 - (27%)
Similarity:	319/684 - (46%)	Gaps:	88/684 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RTARSLQHSLPPPNRYHSHLHPTLRMPWWCMRRGFAQSSKWLARNAKA-NLPTAVGAG---IVPA 100
            |...||:.:|...:|..|             |||.:..|....::..| |....|..|   |...
Mouse   902 RRENSLRRTLSRSSRSGS-------------RRGKSLKSSLKIKSVNALNKKEEVVKGQKLIKKE 953

  Fly   101 PVKMGRSQYGRLLSLTKSEKWVLTAGIGCLVVSSAIT-MSVPLFLGKVIDVVFNKSGMDSAAM-- 162
            .|:.|:.::...|...::..|.....|....|.:.:. :...|:|.........::|.|::..
Mouse   954 FVETGKVKFSIYLKYLQAVGWWSLLFIVIFYVLNYVAFIGTNLWLSAWTSDSEKQNGTDNSPSQR 1018

  Fly   163 -AKLGEYSVL--LFGIFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFDTKGTGE 224
             .::|.:..|  ..|||:|.  ::...::...||:    ::|..:|..::|...:.:|||..||.
Mouse  1019 DMRIGVFGALGIAQGIFLLS--SSLWSIYACRNAS----KTLHRQLLTNILRAPMSFFDTTPTGR 1077

  Fly   225 LINRLSNDTLMVGTSLSQNVSDGLRSVAMIG-VGTGMMIYTSPQLAAVSALVVPAMAGMAIVY-- 286
            ::||.:.|...|..:|.|.:...|  :...| |.|.:||..:..:..:  :::|    ::|:|
Mouse  1078 IVNRFAGDISTVDDTLPQTLRSWL--LCFFGIVSTLVMICMATPIFII--IIIP----LSILYVS 1134

  Fly   287 --------GRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLDEALQIGY 343
                    .|.:||:..|   ..:.|.....|....:..::.|..:|:.:|..:.::|
Mouse  1135 VQVFYVATSRQLRRLDSV---TKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQID------- 1189

  Fly   344 KETRARAIFFGLTG---------FCGNFIII-SVLYYGGTLVLQDSLTIGALTAFML-YAGYVAI 397
              |..:.:|..:|.         ..||.|:. |.|.   .::.::||| |....|:| .|..:..
Mouse  1190 --TNQKCVFSWITSNRWLAIRLELVGNLIVFCSALL---LVIYKNSLT-GDTVGFVLSNALNITQ 1248

  Fly   398 SMNGLSNFYSQLNKGIGASERIWEIL--DRECSIPIDKGVVPLEKP-VGEVGFQNVFFTFPTRPE 459
            ::|.|....|::...|.|.|||.|.:  |.|.....|| ..|.:.| .||:.|.|  :....|||
Mouse  1249 TLNWLVRMTSEVETNIVAVERINEYINVDNEAPWVTDK-KPPADWPKKGEIQFNN--YQVRYRPE 1310

  Fly   460 -SAVLTDFSLNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNNI 523
             ..||...:.|:.......||||:|:||:::...:.|:.:..||.:.:||||:.::....||..:
Mouse  1311 LDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRL 1375

  Fly   524 GAVSQEPVLFSCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLS 588
            ..:.|:|:|||.::|.|:    :|....|.|.:.:.:|.|::..|...|..||...|.:.|..||
Mouse  1376 TIIPQDPILFSGNLRMNL----DPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLS 1436

  Fly   589 GGQKQRVAIARALIKNPAILILDEATSALDAVSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQ 653
            .||:|.:.:.||:::...||:|||||:|:|..:::|:|..:.|.....||:||||||.||.::|:
Mouse  1437 IGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDK 1501

  Fly   654 IAVLSDGKIVEQGSYNELMGIQEGVFRELVASQA 687
            |.||..|||||.||..||:. ..|.| .|:|.:|
Mouse  1502 IMVLDSGKIVEYGSPEELLS-NMGPF-YLMAKEA 1533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	169/612 (28%)
		ABC_membrane	127..395	CDD:279056	62/295 (21%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	88/239 (37%)
Abcc2	NP_038834.2	MRP_assoc_pro	10..1535	CDD:188098	187/684 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..927		8/36 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000