DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and ABCB8

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_001269220.1	Gene:	ABCB8 / 11194	HGNCID:	49	Length:	735	Species:	Homo sapiens

Alignment Length:	740	Identity:	255/740 - (34%)
Similarity:	385/740 - (52%)	Gaps:	110/740 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LCTTLRVRKSSQIRLSTSYNHHLGRCLH---------HRTARSLQHSLPPPNRYHSHLHPTL--- 63
            |...||.:..|.:| :|..|...|: ||         :|::..|        |..:||...|
Human    19 LLPPLRFQTFSAVR-NTWRNGKTGQ-LHKAEGEYSDGYRSSSLL--------RAVAHLRSQLWAH 73

  Fly    64 --RMP----W----WCMRRGFAQSSKWLARNAKANLPTAVGAGIVPAPVKMGRSQYGRLLSLTKS 118
              |.|    |    ||          |:             .|.:..|:.:.:..:..|::|.::
Human    74 LPRAPLAPRWSPSAWC----------WV-------------GGALLGPMVLSKHPHLCLVALCEA 115

  Fly   119 EK--------------------W------VLTAGIGCLVVSSA--ITMSVPLFLGKVIDVVFNKS 155
            |:                    |      :|..|:..::...|  :.:.:||.||::::||...:
Human   116 EEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYT 180

  Fly   156 ----GMDSAAMAKLGEYSVLLFGIFVLGGFANFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGW 216
                |........|..:.::|:|:   .|...|..:.|..:...|:...:|..|:.|:|.|::.:
Human   181 RDHVGSFMTESQNLSTHLLILYGV---QGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITF 242

  Fly   217 FDTKGTGELINRLSNDTLMVGTSLSQNVSDGLRSVAMIG---VGTGMMIYTSPQLAAVSALVVPA 278
            ||...||:|::||:.|.....:|....:|.||||...:.   |...|:   |.:|..:..:..||
Human   243 FDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSML---STRLTLLLMVATPA 304

  Fly   279 MAGMAIVYGRYVRRITKVELDKYAEIMKFAEERFGNVKTVKTFCREQQEVAAFDGKLD----EAL 339
            :.|:..:.|..:|::::...::.|..|..|:|..|||:||:.|..||:|...:..:|:    .|.
Human   305 LMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAE 369

  Fly   340 QIGYKETRARAIFFGLTGFCGNFIIISVLYYGGTLVLQDSLTIGALTAFMLYAGYVAISMNGLSN 404
            ::|    |..|:|.||:....|.:::..|:.||:||....||.|.|.:|::.:..|..||..||.
Human   370 ELG----RGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSV 430

  Fly   405 FYSQLNKGIGASERIWEILDRECSIPIDKG-VVPLEKPVGEVGFQNVFFTFPTRPESAVLTDFSL 468
            .:.|:.:|:.|..|::|.:.....||:..| .||.|:..|.|.||||.|::|.||...||.||:|
Human   431 LFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTL 495

  Fly   469 NLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHLDGIDLRTVNPQWLRNN-IGAVSQEPVL 532
            .|.||...|:||:||.||||:|.|:.|.|||..|.|.|||.||||::|.|||.. :|.:||||||
Human   496 TLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVL 560

  Fly   533 FSCSIRENILYGANPGETPSPERLQQVIEDANVSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAI 597
            |..:|.|||.:|....   |.|.:.....:||..:|....|:|.:|:||:||..||||||||:||
Human   561 FGTTIMENIRFGKLEA---SDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAI 622

  Fly   598 ARALIKNPAILILDEATSALDAVSENLVQNALDNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKI 662
            ||||||.|.:||||||||||||.||.:||.|||....|||||.|||||||:|.|..|.|::||::
Human   623 ARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRV 687

  Fly   663 VEQGSYNELMGIQEGVFRELVASQA 687
            .|.|::.||:. :.|::.||:..||
Human   688 WEAGTHEELLK-KGGLYAELIRRQA 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	229/621 (37%)
		ABC_membrane	127..395	CDD:279056	75/280 (27%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	130/239 (54%)
ABCB8	NP_001269220.1	MdlB	165..713	CDD:224055	224/561 (40%)
ABCB8	NP_001269220.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..735		255/740 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D221577at33208
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730