DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3156 and abcb10

DIOPT Version :9

Sequence 1:	NP_569844.2	Gene:	CG3156 / 30994	FlyBaseID:	FBgn0023536	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	XP_001343218.3	Gene:	abcb10 / 100003744	ZFINID:	ZDB-GENE-040525-2	Length:	710	Species:	Danio rerio

Alignment Length:	709	Identity:	320/709 - (45%)
Similarity:	449/709 - (63%)	Gaps:	53/709 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LNCTRLT---HLCTTLRVRKSSQIRLSTSYN-----HHLGR------CLHHRTARSLQHSLPPPN 53
            :.|.|.:   |..|......|.|:|.:.|::     .:.||      ||......|.:||
Zfish    21 ITCCRSSTFHHWSTRTSRTWSRQVRKNGSFDICVLPVYKGRNISKLSCLRTEGLFSPKHS----- 80

  Fly    54 RYHSHLHPTLRMPWWCMRRGFAQSSKWLARNAKANLPTAVGAGIVPAPVKMGRSQYGRLLSLTKS 118
            |:...|:.|        .....|:||.:.....:...||....:....||       :||.|...
Zfish    81 RHIVALYST--------STDSNQTSKSVVNQESSAKTTADSLPVPSEDVK-------KLLQLAHP 130

  Fly   119 EKWVLTAGIGCLVVSSAITMSVPLFLGKVIDVVFNKSGMD-SAAMAKLGEYSVLLFGIFVLGGFA 182
            ::|.|||.:|.||:||.:|||.|.|||||||.::.....| |:::..|   .::|.|:|:.||.|
Zfish   131 QRWRLTAAVGFLVISSTVTMSAPFFLGKVIDTIYTSPTEDFSSSLTSL---CLMLTGVFLCGGAA 192

  Fly   183 NFARVHLFGNAALRIVRSLRSRLYRSMLMQEVGWFDTKGTGELINRLSNDTLMVGTSLSQNVSDG 247
            |.|||:|...:..:|||.||..|:.|:|.||:|:||...|||||||||.||.:||..|:.|:|||
Zfish   193 NAARVYLMQISGQQIVRKLRESLFSSILKQELGFFDKTRTGELINRLSADTAIVGRCLTDNLSDG 257

  Fly   248 LRSVAMIGVGTGMMIYTSPQLAAVSALVVPAMAGMAIVYGRYVRRITKVELDKYAEIMKFAEERF 312
            |||:|..|.|.|||:|.||.|||...:|||.:|.:|:::||::|.|::...|..||..:.||||.
Zfish   258 LRSLAQAGAGVGMMLYVSPSLAAFVLMVVPPIACLAVIFGRFLRSISRRTQDALAEATQLAEERI 322

  Fly   313 GNVKTVKTFCREQQEVAAFDGKLDEALQIGYKETRARAIFFGLTGFCGNFIIISVLYYGGTLVLQ 377
            .|::||:.|.:|..||..:..|:|...::..||....|.|:|:||..||.||:||||.||.|:..
Zfish   323 SNLRTVRAFGKELTEVQKYSQKVDHIFELAKKEAVVSAGFYGVTGLSGNVIILSVLYKGGLLMAS 387

  Fly   378 DSLTIGALTAFMLYAGYVAISMNGLSNFYSQLNKGIGASERIWEILDRECSIPIDKG-VVPLEKP 441
            :::|:|.|::|::||.:|.||:.|.|:|||:|.||:||..|:||::||:...|:::| |:..|..
Zfish   388 EAMTVGQLSSFLMYAFWVGISIAGFSSFYSELMKGLGAGTRLWELIDRKPEFPLNEGLVLTSELL 452

  Fly   442 VGEVGFQNVFFTFPTRPESAVLTDFSLNLMPGTTTAVVGRSGSGKTTIALLMLRLYDPQGGTVHL 506
            .||:.|:||.|.:|||.:|.:..|.||::..|:..||||.|||||:::..|:||||||..|.|.:
Zfish   453 KGELEFRNVSFAYPTRKDSPIFQDLSLHVPAGSVLAVVGSSGSGKSSLVSLLLRLYDPDSGIVSV 517

  Fly   507 DGIDLRTVNPQWLRNNIGAVSQEPVLFSCSIRENILYGANPGETPSPERLQQVIED-------AN 564
            ||.|:|.:||.|||::||.||||||||||||.|||.|||       |:..|..:||       ||
Zfish   518 DGHDIRDLNPYWLRSHIGTVSQEPVLFSCSIAENIAYGA-------PDPSQVTVEDIYRAAQIAN 575

  Fly   565 VSQFTDQLPDGLDTLVGQRGMMLSGGQKQRVAIARALIKNPAILILDEATSALDAVSENLVQNAL 629
            ...|..:.|.|.||:||::|::|||||||||||||||:|||.||:||||||||||.:|.|||.||
Zfish   576 AHDFIQEFPKGYDTVVGEKGVLLSGGQKQRVAIARALLKNPKILLLDEATSALDAENEFLVQEAL 640

  Fly   630 DNLIQGRTVLTIAHRLSTIRNADQIAVLSDGKIVEQGSYNELMGIQEGVFRELVASQAF 688
            :.|:.|||||.||||||||::||.:|||...:::|.||:::|:...:|:||:|:..|||
Zfish   641 ERLMDGRTVLIIAHRLSTIQSADSVAVLDQHRVMEIGSHSQLLANDQGLFRKLMEKQAF 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3156	NP_569844.2	MdlB	106..687	CDD:224055	292/589 (50%)
		ABC_membrane	127..395	CDD:279056	125/268 (47%)
		ABC_MTABC3_MDL1_MDL2	447..686	CDD:213216	136/245 (56%)
abcb10	XP_001343218.3	MsbA_rel	123..697	CDD:131259	292/583 (50%)
		ABC_membrane	141..402	CDD:279056	122/263 (46%)
		P-loop_NTPase	457..697	CDD:304359	136/246 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594374
Domainoid	1	1.000	243	1.000	Domainoid score	I2174
eggNOG	1	0.900	-	-		E2759_KOG0058
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6474
Inparanoid	1	1.050	568	1.000	Inparanoid score	I1033
OMA	1	1.010	-	-		QHG54509
OrthoDB	1	1.010	-	-		D221577at33208
OrthoFinder	1	1.000	-	-		FOG0000243
OrthoInspector	1	1.000	-	-		oto40563
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1969
SonicParanoid	1	1.000	-	-		X2387
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800