Protein Alignment CG18273 and URB2

DIOPT Version :9

• Sequence 1: NP_569843.2
• Gene: CG18273 / 30991
• FlyBaseID: FBgn0029525
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_001300950.1
• Gene: URB2 / 9816
• HGNCID: 28967
• Length: 1524
• Species: Homo sapiens
• Alignment Length: 1708
• Identity: 329/1708 - (19%)
• Similarity: 567/1708 - (33%)
• Gaps: 538/1708 - (31%)

  Fly     3 TGEALKSWLTETNKPFAARVEFALKVWQSVEFPYLNKYEVIADWLAKSLGGC--KDLPFQQ---- 61
            :|.:||  |......:..:::.|...|.|.:....||.:|:.||..:||...  |.|..::
Human     6 SGISLK--LKSKTTSWEDKLKLAHFAWISHQCFLPNKEQVLLDWARQSLVAFYKKKLELKEDIVE 68

  Fly    62 ------------------LKDFLRLRAQPGWV--------------TQTTKCQLIHALYEIVSRE 94
                              ||:...:..|...|              :|...|.::.....|:|..
Human    69 RLWIYIDNILHSRKLQNLLKNGKTINLQISLVKIINERVAEFSLSGSQRNICAVLRCCQGILSTP 133

  Fly    95 ENA-NESALEVLPMVLSSELLQDALRSSN----KLLFE----CYGSLFRCHQKCVELRKDNKDRT 150
            ..| ..:|.:.|.:.|.|:|...|.|...    ..|||    ..|......|:.|..|:...|.|
Human   134 ALAVIYTAKQELMVALLSQLCWSACRQPEGAVVAQLFEVIHLALGHYLLILQQQVNPRRAFGDVT 198

  Fly   151 ESQDHWDAEFVVP--VIKQLTEMVRRSQEPEKLLEEYNSKTVRPLV-----------ELHLTLKT 202
                   |..:.|  |::.|......:|..:..|.:..|:.:|..:           ||..:.|.
Human   199 -------AHLLQPCLVLRHLLSGGTWTQAGQGQLRQVLSRDIRSQIEAMFRGGIFQPELLSSYKE 256

  Fly   203 SCLDE-----LAELEKQIKAEFD--ITRIKD-----LPLHVSLI-----LLEASVLNNRFQTANI 250
            ..||:     .....|.:.|..|  :.|:.|     ..||.|::     ||....|::.|:..|
Human   257 GLLDQQQGDVKTGAMKNLLAPMDTVLNRLVDAGYCAASLHTSVVANSVALLYKLFLDSYFKEGN- 320

  Fly   251 STILLC------IF-----------NTEALSQS----SLQLTAHFLMSLRK---YNVSL-QFKLE 290
              .|||      :|           .::|||.|    .|.:....|.|:..   ||::. :.:.|
Human   321 --QLLCFQVLPRLFGCLKISHLQEEQSKALSTSDWTTELLVVEQLLNSVANNNIYNIAADRIRHE 383

  Fly   291 NLSITAFAYVSDQLLRLVREYKKSNLKEVLILLCSALRYNPLLLEQSVYQI--TVWMLTTPKENA 353
            ......:.:|::.|:    .:.::.:......|.:.:..|.|:||..:..:  :.|:      :|
Human   384 EAQFRFYRHVAELLI----NHAQAPIPAWFRCLKTLISLNHLILEPDLDDLLASAWI------DA 438

  Fly   354 QVEELYSEYLILLLDMFRRLSRAERFIINLLKVLGAWLGKYTLDVPPNEAKKRRIQDSKIIEAEG 418
            :|.|.             |..:|:..:|.              .|....||.|::.
Human   439 EVTEF-------------RTKKAQEALIR--------------TVFQTYAKLRQVP--------- 467

  Fly   419 HQLEERFLGIIFNRTPLATAPSANDAFKQLCQTWPSHSAGVAFTRLISNLMSKPSLVI--WKSLL 481
             :|.|..||:|       ..|:| :|.:|     |..::|.:.......|...||.::  |..:|
Human   468 -RLFEEVLGVI-------CRPAA-EALRQ-----PVLASGPSTVLSACLLELPPSQILDTWSLVL 518

  Fly   482 HSFAELLEEDQPKEVLP---ENLDFA-RELHAALL--CQYLNGTRLAEQVQLYQLQVEQQLQHTC 540
            ..|..|        |||   .:.|.| :.|..:||  |...|...|.....|      ..::.|.
Human   519 EKFQSL--------VLPYLQSDADMALKSLSLSLLLHCIMFNMRSLDSSTPL------PIVRRTQ 569

  Fly   541 QVLEQFGRLLLRQEHNRRLMNAFLECT---------ERASGFELLLAYYWPD------------- 583
            .::|:..|.|::.      :.|.|..|         ::.|...|||:|.|..
Human   570 CMMERMMRELVQP------LLALLPDTPGPEPELWLQKVSDSVLLLSYTWAQVDAMFSLNCSQYH 628

  Fly   584 ---------GFPASQRPVQLRGFLPTAEWTLIQQRVYNF---GKNCC-RLRLQRLELQLVESGWL 635
                     ....|..|..|.| :.|..|..|::....|   |..|. :|.||:::..|:::.:
Human   629 SMSGPLIGVALEISNLPSLLPG-VKTQHWKKIEKFTAQFSSLGTYCLEQLYLQKMKRTLMQTSF- 691

  Fly   636 LKDQRGA----NCSDALAELVPPYQLFRLSRPQKQLRLHQRKHNQSLEP---------------- 680
              ...||    .|..|          |.:...:|.|       ||....
Human   692 --RSEGAIQSLRCDAA----------FIIGSGRKSL-------NQRTTASWDGQVGMVSGLTYPV 737

  Fly   681 ---HLNDSESIEILTLQLLKEYGAEAKEAKAKGSLLVKLKLEEQVEENSLTQFLRDNASVEID-- 740
               ||..|....:::.....:.|..|       |:|::.....:.:|.|:.    :.|.:.::
Human   738 AHWHLIVSNLTILISYLCPDDVGYLA-------SVLLRTLPMGKAQEVSID----EEAYITLEKI 791

  Fly   741 ----LHLP--P-----------------AQVLVKTLQ---GLPLAQLPRNIRSRLWL-------- 771
                ||.|  |                 :.:|....|   ||...|||       ||
Human   792 SKAFLHSPLFPEMQSLHSAFLTCVTTSCSSILCSGAQRDSGLVSQQLP-------WLFEKDHMVV 849

  Fly   772 ------------------------VIFVLYRDLSLSHQEENANQILELL--IDLMHFGHPLP--I 808
                                    ::.::..|..:..:.|....||.||  |..:.....||  .
Human   850 GHWENRFAKAGPEGIEPRGEIAQNLLSLVKSDFPIQLEGEQLESILGLLEVISALQLDSLLPPYH 914

  Fly   809 CSYF-----PRLSELLCLIPTSSTVGWSFYETLF-----------ARCIRRQGAGSEAFLASCTG 857
            ..||     ..:::|.|  ..||::...|..|.:           ||.:.:...||:.|....|.
Human   915 VHYFLVLLSMAVTKLGC--SCSSSLALKFLTTCYQLLGYLQKGKSARSVFKIMYGSDIFEVVLTS 977

  Fly   858 FFKDQLAALNKLPAEERRLLLLA----IETLSSVTGAQGRRLQGQLQPLIQIYGEMVTH-----K 913
            .|:          |..|.|:.:.    :|.|..:    |..|:..:|.|||:...:|.:     .
Human   978 LFR----------ASSRFLIEMDDPAWLEFLQVI----GTFLEELMQMLIQMKLSLVLNFRKITA 1028

  Fly   914 FRSKKK---EASAYKEFVDSTLSG------YATYVSNCINSVVRWEREEQKKRNESESSEKTKAE 969
            |.|..|   ||::.|:..:....|      ..|.:.:.:...::    |||...|:.::.....:
Human  1029 FLSSSKPYTEAASSKQLENQNPQGRQLLLVSLTRLCHVLGPFLK----EQKLGQEAPAALSELLQ 1089

  Fly   970 PKVDHKKKNRDPETAKIQEL-EDNGKQ--RQPKLIDENFRRICKIYIGHSLNYRDANA------- 1024
            ..|        .:|..:.:| ...|.:  |.|.::..:...:.:..:|.  :.||..|
Human  1090 QVV--------LQTGAVLQLCSVPGARGWRLPSVLISSVSTLLEADLGQ--HCRDGGADISQGSD 1144

  Fly  1025 -TRLLNVAL----------------THRQ----------------RLHLDPDEIEFVLSSYWRQL 1056
             |.|.:|||                .|.|                .||...|.:...:....|::
Human  1145 RTLLSHVALYQGVYSQILLELPALAGHDQSFQAALQFLTLFFLAPELHPKKDSVFTSMFHSVRRV 1209

  Fly  1057 NTDIEVGDTFSSSALDCLEPAI------KLIIGYKTNEDFLLLLHRL--SSQVEQMARPASQTEH 1113
            ..|.|:....:..    :||.:      .|.:|  |.||..|::..:  ...|..|.:...|
Human  1210 LADPEIPVQVTQD----IEPHLGALFTQMLEVG--TTEDLRLVMQCILQGLDVSNMWKADVQ--- 1265

  Fly  1114 TALQNVLTLLALFAKCSLSSVKGAMLNEHFEVISVSVAL-----RLPEPKDLAYSGHAL----RL 1169
             |:.:.:|||.|...|.||..|.::|......|..::.|     ...:|..|...|..|    .|
Human  1266 -AVVSAVTLLRLLLNCPLSGEKASLLWRACPQIVTALTLLNREASQEQPVSLTVVGPVLDVLAAL 1329

  Fly  1170 LEAQRNLAGNRTVPLTGESLDCLLSSMLDIDIKHL--ISHGGSWQQFVDLYSALTDNLIVLLKQH 1232
            |.......||      ...:....|.:|.:.:.||  :.:|       .::..|.:.|..:|:.|
Human  1330 LRQGEEAIGN------PHHVSLAFSILLTVPLDHLKPLEYG-------SVFPRLHNVLFSILQCH 1381

  Fly  1233 SNLMSDRAAQLSVLCQDLIQAVV--GYRAERKQTQDISETELDGLADLGLKLATVMATVRATQAL 1295
            ..:|.............|:.:|:  |.:.::....|               |.||:...|..:.:
Human  1382 PKVMLKAIPSFLNSFNRLVFSVMREGRQKDKGSIDD---------------LPTVLKCARLVERM 1431

  Fly  1296 ---AVKRVAPFLLI--FTIRQMVATERPTTLFEKIKVHIVRVCHELIGICDHRAGHFILRSSNEA 1355
               ...|...|.:.  |.:.|.|...:..||:..:|..:....:.::.:|......| ||:|.:.
Human  1432 YSHIAARAEEFAVFSPFMVAQYVLEVQKVTLYPAVKSLLQEGIYLILDLCIEPDVQF-LRASLQP 1495

  Fly  1356 GAR-MYEGLVKDHEKYHK 1372
            |.| :::.|..|:.||||
Human  1496 GMRDIFKELYNDYLKYHK 1513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18273	NP_569843.2	Urb2	1167..1372	CDD:287422	42/218 (19%)
URB2	NP_001300950.1	Urb2	1322..1516	CDD:313635	44/221 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D319328at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010