DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18273 and Urb2

DIOPT Version :9

Sequence 1:	NP_569843.2	Gene:	CG18273 / 30991	FlyBaseID:	FBgn0029525	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	XP_038953581.1	Gene:	Urb2 / 292087	RGDID:	1307980	Length:	1545	Species:	Rattus norvegicus

Alignment Length:	1712	Identity:	337/1712 - (19%)
Similarity:	572/1712 - (33%)	Gaps:	535/1712 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LKSWLTETNKPFAARVEFALKVWQSVEFPYLNKYEVIADWLAKSLGGC--KDLPFQQ-------- 61
            |||..|.    :..:::.|...|.|.:....||.:|:.||..:||...  |.|..|:
  Rat    12 LKSKTTS----WEDKLKLAHFAWISHQCFLPNKEQVLLDWARQSLVAFYKKKLELQEDIVERLWV 72

  Fly    62 ----------LKDFLR-----------------------------------------LRAQPGWV 75
                      |::.|:                                         |.|....|
  Rat    73 YVDNILHSRRLQNLLKNGKTINLQISLVKIINEKIEEFSLSGSQRSICAILSCCQGILSAPALAV 137

  Fly    76 TQTTKCQLIHAL-----YEIVSREENANESAL-EVLPMVLSSEL-LQDALRSSNKLLFECYGSLF 133
            ..|.|.:||.||     :....:.|.|..:.| ||:.:.|...| ||....:..::..:..|.||
  Rat   138 IYTAKPELIVALLSQLCWSACRQPEGAMTAKLFEVIHLALDHYLKLQQQQANPRRVFGDMTGHLF 202

  Fly   134 RCHQKCVELRKDNKDRTESQ----DHWDAEFVVPVIKQLTEMVRR---------SQEPEKLLEEY 185
               |.|:.||......|.:|    ..|  :.:...|:...:.|.|         |...|:|||:.
  Rat   203 ---QPCLVLRHLLLGGTWTQASQGQLW--QVLSRDIRSKIDAVLRGGVFRYDLLSSYKEELLEQQ 262

  Fly   186 NSKTVRPLVELHLTLKTSCLDELAELEKQIKAEFDITRIKDLPLHVSLILLEASVLNNRFQTANI 250
            .......:::..||...:.:..|.|.: .:|::          ||..::....|:|...|..:.:
  Rat   263 QENVKMGVLKNLLTPMDTVITRLVEPD-YVKSD----------LHALVVASSVSLLYRLFLDSYL 316

  Fly   251 --STILLC------IFNTEALSQSSLQLTAHFLMSLRKYNVSLQFKLENLSI---TAFAYVSDQL 304
              ....||      :|.  .|..|.||                :.::|.||:   |......:||
  Rat   317 KEENQFLCFQVLPRLFG--CLQISHLQ----------------EGQMEALSLSDWTTELLAVEQL 363

  Fly   305 LRLVREYKKSNLKEVLILLCSALRYN-----------PLLLEQSVYQITVWMLTTPKENAQVEEL 358
            |.||   ..||:..|   ....:|:.           .||:..|...:..|...       ::.|
  Rat   364 LNLV---ATSNIYNV---AADRIRHGETQFHFYRRVAELLINHSQASVPAWFRC-------LKIL 415

  Fly   359 YS-EYLILLLDMFRRLSRAERFIINLLKVLGAWLGKYTLDVPPNEAKKRRIQDSKI-----IEAE 417
            .| .:|||..|:...||             .||     :|....|.:.::.|:..|     ..|:
  Rat   416 MSLNHLILEPDLDDLLS-------------SAW-----IDAEVTEFRAKKAQEVLINTVFQTYAK 462

  Fly   418 GHQLEERFLGIIFNRTPLATAPSANDAFKQLCQTWPSHSAGVAFTRLISNLMSKP---SLVIWKS 479
            ..|:.:.|..::    .:...|:| :|.:|     |..::|::.. |.:..:..|   .|..|..
  Rat   463 LRQMPQLFQELL----EVICRPAA-EALRQ-----PLLASGLSMA-LCACFLELPLSQILDTWSL 516

  Fly   480 LLHSFAELLEEDQPKEVLPENLDF---ARELHAALLCQYLNGTRLAEQVQLYQLQVEQQLQHTCQ 541
            :|..|..|:     ...|..:.|.   |..|.:.|.|...|...|...:.|      ..::.|..
  Rat   517 VLDKFQSLV-----MPCLQSDTDMAFKAMSLSSLLHCIMFNMQSLDNNMPL------PIIRRTQC 570

  Fly   542 VLEQFGRLLLRQEHNRRLMNAFLEC--------TERASGFELLLAYYWPD--------------- 583
            ::|:..|.|::.     |:...|:.        .::.|...|||:|.|..
  Rat   571 MMERMLRELVKP-----LLGLLLDLWSPEPEPWQQKVSDSALLLSYTWAQVDTTLSLHCSQYYSL 630

  Fly   584 -------GFPASQRPVQLRGFLPTAEWTLIQQRVYNFGKNCCRLRLQRLELQLVESGWLLKDQRG 641
                   ...:|..|:.|.| :.|..|..:::.:.. .::..|..|::|.||.|:...:   :..
  Rat   631 AVSLARAALDSSNLPLLLPG-VETELWKKVEKCIAQ-SRSLSRYCLEQLYLQKVKRTLI---RTS 690

  Fly   642 ANCSDALAEL-VPPYQLFRLSR---PQKQLRLHQRK---HNQSLEP----H-------------- 681
            :...:||..| .....:...||   .||.:....|:   .|:||.|    |
  Rat   691 SQSKEALQTLRFDTAHILDSSRDCLSQKTVTAWDRQVSTMNESLYPVAHWHLIVSNLTVLIPYLC 755

  Fly   682 LNDSESIEILTLQLLKEYGAEAKEAKAKGSLLVKLKLEEQVEENSLTQFLRDNASVEIDLHLPPA 746
            |||...:..:.|:.|       ..:||:|||...   |..|....::..|         ||.|
  Rat   756 LNDVRYVATVLLRTL-------PTSKAQGSLAPG---ESYVTLEKISTAL---------LHSP-- 799

  Fly   747 QVLVKTLQGLPLAQLPRNIRSRLWLVIFVLYRDLSLSHQ-------------------------- 785
              |...:|.|..|.|...|.....::....:.|||||.|
  Rat   800 --LFPEMQSLYSAFLTCIIAKCSNILCSGAHNDLSLSQQLPWLFGKDYHTLVAHWETRLAKVGSE 862

  Fly   786 -EENANQILELLIDLMHFGHPLPICSYFPRLSELLCLIPTSSTVG----WSFYET-----LFARC 840
             .|...:|.:..:.::..|.|:.:  :..:|.:||.|....|.:.    |..|..     ||:..
  Rat   863 GVEPRGEIAQNFLSMVKSGFPIKL--HEDQLKDLLELFDVISALHLDSLWPSYHVHLFFLLFSMA 925

  Fly   841 IRRQGAGS----EAFLASC----------------------TGFFKDQLAALNKLPAE------- 872
            :...|..|    ..||..|                      :..|:..|.:|.:..||
  Rat   926 VSTLGHCSCPLALQFLVKCYQLLSGLQRGRNARSVFRVMYVSDIFEVVLTSLLQASAEFQVREDD 990

  Fly   873 ERRLLLLAIETLSSVTGAQGRRLQGQLQPLIQI-------YGEMVTHKFRSKKKEASAYKEFVDS 930
            ...|.||.:         .|..|:..:|.|||.       :|::..  |.||..:.::.||....
  Rat   991 PAWLQLLQV---------SGVFLEQLMQMLIQAKLSLVLNFGKITA--FLSKYSKGASSKELNIQ 1044

  Fly   931 TLSG------YATYVSNCINSVVRWEREEQKKRNESESSEKTKAEPKVDHKK------------- 976
            .|..      ..|.:...:...|:..|         :..|...|.|::..:.
  Rat  1045 NLRSRQLLLVALTKLCQSLGPCVKERR---------QLLEAPAALPELLQQAMMQMGAMLQLCLV 1100

  Fly   977 ------KNRDPE-------TAKIQELEDNGKQRQPKL---IDENFRRICKIYIGHSLNYRD---- 1021
                  :.|.|.       |....:|..:.::.|||:   :|.:     :..:.|...|:|
  Rat  1101 PGTTGCRRRLPSVLLSAVPTLLEVDLSQHLREGQPKIAQVVDTD-----RALLSHVTLYQDVYTQ 1160

  Fly  1022 --------ANATRLLNVALTHRQRLHLDPDEIEFVLSSYWRQLNTDIE---VGDTFSSSALDCLE 1075
                    :..|:....||.......|.| |.....||.:..:...::   .|....:......|
  Rat  1161 LLEELPALSGNTQSFQAALRFLTLFLLAP-EFHSKESSVFASIFYSVQKVLTGPCIPAPVTQDTE 1224

  Fly  1076 PAIKLIIGY----KTNEDFLLLLHRLSSQVEQMARPASQTEHTALQNVL---TLLALFAKCSLSS 1133
            |.:..::..    :|.|.|.::|..:...::     .:|...:.||.||   .||.|..||.||.
  Rat  1225 PHLGALLTQMFKAETTEHFGMVLQSILQGLD-----VTQAWRSDLQVVLCAIRLLNLLLKCPLSG 1284

  Fly  1134 VKG------------AMLNEHFEVISVS-VALRLPEPKDLAYSGHALRLLEAQRNLAGNRTVPLT 1185
            .|.            |::.:|.|..... |||.:.||   .....|:.|.:.:.:::....|.|.
  Rat  1285 EKASLLWRSCPQIVTALMLQHREACQEQPVALVVVEP---ILEVLAVLLRKGEESISNPHHVNLA 1346

  Fly  1186 GESLDCLLSSMLDIDIKHLISHGGSWQQFVDLYSALTDNLIVLLKQHSNLM---------SDRAA 1241
                   .:.:|.:.::||     ..::|..::....:.|..:|:.||.:|         |....
  Rat  1347 -------FNILLTVPLEHL-----KPREFGSVFLKTHNVLFSILQCHSKVMLKAIPSFLNSFNRL 1399

  Fly  1242 QLSVLCQDLIQAVVGYRAERKQTQDIS---------ETELDGLADLGL--KLATVMATVR----- 1290
            .||||            .|.:|...:.         .:..|.|..:|.  .|..|:...|
  Rat  1400 LLSVL------------HEGRQKDQVKRWGQERCSCHSNADHLPSVGSMDDLPVVLECARLVERM 1452

  Fly  1291 ----ATQALAVKRVAPFLLIFTIRQMVATERPTTLFEKIKVHIVRVCHELIGICDHRAGHFILRS 1351
                ||:|......:|||    :.|.|...:..||:..:|..:....:.::.:|..|...| ||:
  Rat  1453 YSHIATRAEEFTTFSPFL----VAQYVTEVQKVTLYPPVKNLLQEGIYLILDLCMERDIQF-LRA 1512

  Fly  1352 SNEAGAR-MYEGLVKDHEKYHK 1372
            |.::||| :::.|..|:.||||
  Rat  1513 SLQSGARDVFKDLHSDYLKYHK 1534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18273	NP_569843.2	Urb2	1167..1372	CDD:287422	49/234 (21%)
Urb2	XP_038953581.1	Urb2	1322..1538	CDD:402186	52/242 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D319328at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010