DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g1 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	532	Identity:	149/532 - (28%)
Similarity:	248/532 - (46%)	Gaps:	69/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYLNKYGETMKAWL 99
            ||.|...:.:.|..|..|.::..|.||...:||....... .|.|.|.   ..:.|:......|:
Mouse    24 LVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQKFLQE-DNMETLD---EIVKKHPCAFPCWV 84

  Fly   100 GNVLLVF-LTNPSDIELILSG--------HQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMI 155
            |.....| :.:|...::.||.        ||.||         |..|.|||..:|..|..||.::
Mouse    85 GPFQAFFYIYDPDYAKIFLSRTDPKMQYLHQLLT---------PCIGRGLLNLDGPRWFQHRCLL 140

  Fly   156 APTFHQSILKSFVPTFVDHSKAVV----ARMGLEAGKSFDVHDYMSQTTVDILLSTAMGVKKLPE 216
            .|.|||.|||..|.|.. ||..|:    .:|......:.:|.::::..|:||::..|.|.:...:
Mouse   141 TPAFHQDILKPCVDTMA-HSVKVMLDKWEKMWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQ 204

  Fly   217 GNKSFE-YAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKG---DRMMNIILGMTSKVVKDRK 277
            .|.::| |.:|..::.:||..|.....:..|.|:   ||..||   ..:..:|...|.|:::|||
Mouse   205 INGTYESYVKATFELGEIISSRLYNFWHHHDIIF---KLSPKGHCFQELGKVIHQYTEKIIQDRK 266

  Fly   278 ENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWN 342
            :..:.:.:.                        ||...:.:       .||.::......:..::
Mouse   267 KILKNQVKQ------------------------DDTQTSQI-------FLDIVLSAQAEDERAFS 300

  Fly   343 EKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMK 407
            :.|:..||||.|:.|||.::|..|:.|..:.::.:.|.:...|.::|.||.  ...|:....||.
Mouse   301 DADLRAEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDG--SSITWEQLDEMS 363

  Fly   408 YLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPD 472
            |....|.|||||.||||.|:|.|...|.|..| :::|.|.||::..:.:|..|.::.:|..|||.
Mouse   364 YTTMCIKETLRLIPPVPSISRELSKPLTLPDG-HSLPAGMTVVLSIWGLHHNPAVWNDPKVFDPL 427

  Fly   473 NFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIIL 537
            .|..|....||..:|:|||:|||:|:|:::|||:|||.::.|:.::.| :.|........:..:|
Mouse   428 RFTKENSDQRHPCAFLPFSSGPRNCIGQQFAMLELKVAIALILLHFQV-APDLTRPPAFSSHTVL 491

  Fly   538 KLENGFNVSLEK 549
            :.::|..:.|:|
Mouse   492 RPKHGIYLHLKK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	137/476 (29%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	141/503 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920