Protein Alignment Cyp4g1 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 127/613 - (20%)
• Similarity: 244/613 - (39%)
• Gaps: 121/613 - (19%)

  Fly    22 LGF------SPMLTTLVGTLVAMALYEYWRRN--SREYRMVANIPSPPELPILGQ-AHVAAGLSN 77
            |||      .||:|..: ::..:||.:::..:  ||..::....|.|.  |.:|. .....|...
Human     4 LGFLKLEVNGPMVTVAL-SVALLALLKWYSTSAFSRLEKLGLRHPKPS--PFIGNLTFFRQGFWE 65

  Fly    78 AEILAVGLGYLNK-YGETMKAWLGNVLLVFLTNPSDIELIL------------SGHQHLTKAEEY 129
            :::      .|.| ||.....:||..:.:.::.|..|:.:|            ||.:..:.|:..
Human    66 SQM------ELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSV 124

  Fly   130 RYF--KPW----------FGD------GLLIS----NGH-HWRHHRKMIAPT-----------FH 160
            .:.  |.|          |..      ||||.    .|| ..:...:.|.||           .|
Human   125 LFLRDKRWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLH 189

  Fly   161 QSILK-SFVPTFVDHSKAVVARMG--LEAGKSFDVHDYMSQTTVDILLSTAMGVK----KLPEGN 218
            .:.|. ..||........::|.:.  .|:|.:||:.......|.|::.|.|.|..    :.|| :
Human   190 YATLPFCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPE-D 253

  Fly   219 KSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYK-----------------FTKLREKGDRMMNIIL 266
            ...::.:...:.|  |.:..:.||....||..                 |.||      :.|:|.
Human   254 PFVKHCKRFFEFC--IPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKL------IRNVIA 310

  Fly   267 GMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDE--NDVGAKRRLALLDA 329
            ....:..::|:.:|          :...:.:..::...|:: |.|.:.:  :..|.|...:....
Human   311 LRDQQAAEERRRDF----------LQMVLDARHSASPMGVQ-DFDIVRDVFSSTGCKPNPSRQHQ 364

  Fly   330 MVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNM 394
            ...||:...::    :|:.:....:..|::..:...|||..::..:.|.|.|:..|.......:|
Human   365 PSPMARPLTVD----EIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHM 425

  Fly   395 LRD-CTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHR 458
            ..: |:..:  .:.||:.||.||||:|||.....|....|.::..  ..:|.|..:.:....:|.
Human   426 APEFCSLEE--GLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLG--QRIPAGAVLEMAVGALHH 486

  Fly   459 RPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHS- 522
            .|:.:|:|..|:|:.|..|.......::::||.||||||:|.:..:|::|:.|..::..:...:
Human   487 DPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQAC 551

  Fly   523 TDTEADFKLQADIILKLENGFNVSLEKR 550
            .:|:...:|::...|..:||..:.:..|
Human   552 PETQVPLQLESKSALGPKNGVYIKIVSR 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	108/526 (21%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	109/527 (21%)