DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g1 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001093657.1	Gene:	Cyp4f37 / 677156	MGIID:	3780112	Length:	546	Species:	Mus musculus

Alignment Length:	547	Identity:	150/547 - (27%)
Similarity:	259/547 - (47%)	Gaps:	58/547 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 STTVLGFSPMLTTLVGTLVAMAL---YEYWRRNSREYRMVANIPSPPELP-ILGQAHVAAGLSNA 78
            |...|.:..:|......::|..|   |.:....||    :...|.||:.. .||  |:.....|.
Mouse    13 SVVTLSWHLLLLGAASWILARILAWTYSFCENCSR----LRCFPQPPKRNWFLG--HLGMIEHNE 71

  Fly    79 EILAVGLGYLNKYGETMK----AWLGNVLLVF-LTNPSDI-ELILSGHQHLTKAEEYRYF-KPWF 136
            |    |:..:.:.|:|.:    .|||.|:.|. :.:|:.: .|:|:......|...:..| |||.
Mouse    72 E----GMQLMTEAGQTYRDVHLCWLGPVIPVLRIVDPAFVAPLLLASALVAPKDTTFHTFVKPWL 132

  Fly   137 GDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTF-----VDHSKAVVARMGLEAGKSFDVHDYM 196
            ||||.:::|..|..||:::.|.||..|||.:|..|     :.|:|  ...:..|.....::.:::
Mouse   133 GDGLFLNSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAK--WKHLSSEGSARLEMFEHI 195

  Fly   197 SQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRM 261
            |..|:|.|.....|.....:.:.| ||..|::::..::.||..:|...:|.:|..|....:..:.
Mouse   196 SLMTLDSLQKCLFGFDSNCQESPS-EYISAILELSSLVIKRSHQLFLFVDFLYYHTADGRRFRKA 259

  Fly   262 MNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLAL 326
            .:::...|..|:::|:.....::.   :|.   :.|...||      .||.||          .|
Mouse   260 CDLVHNFTDAVIRERRHTLSSQNH---DEF---LKSKTKSK------TLDFID----------VL 302

  Fly   327 LDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFG 391
            |.|..|..|    |.:::||..|.:|.||.|||||::..|:.|..:..|.:.|.:...|.:.:..
Mouse   303 LLAKDEHGK----ELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLR 363

  Fly   392 DNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCV 456
            ....::..:.|..::.:|...|.|:|||:|||..:.||...|:.|..| ..:|||...::..:.:
Mouse   364 GREPQEIEWDDLAQLPFLTMCIKESLRLHPPVIDLLRRCTRDIVLPDG-RVIPKGNICVISIFGI 427

  Fly   457 HRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVH 521
            |..|.::|:|..:||..|.||....|...:|||||||||:|:|:.:||.::.|.|:..:..:.:.
Mouse   428 HHNPSVWPDPEVYDPFRFDPENAHKRPPLAFIPFSAGPRNCIGQTFAMNEMMVALALTLLRFRIL 492

  Fly   522 STDTEADFKLQADIILKLENGFNVSLE 548
            ..|.|.  :.:.:|||:.|.|..:.:|
Mouse   493 PDDKEP--RRKPEIILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	134/472 (28%)
Cyp4f37	NP_001093657.1	CYP4F	74..515	CDD:410772	132/472 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920