DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	559	Identity:	147/559 - (26%)
Similarity:	265/559 - (47%)	Gaps:	75/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LGFSPMLTT-------LVGT-LVAMAL---YEYWRRNSREYRMVANIPSPPE-------LPILGQ 68
            ||..|:.|:       :||: |:|..|   |.:: .|.|..:.   .|.||:       |.::
Human     9 LGLRPVATSPWLLLLLVVGSWLLARILAWTYAFY-NNCRRLQC---FPQPPKRNWFWGHLGLI-- 67

  Fly    69 AHVAAGLSNAEILAVGLGYLNKYGETMKAWLGNVL-LVFLTNPSDIELILSGHQHLTKAEE--YR 130
            .....||.|:..::.      .|.:....|||.:: .:.|.:|..|..|.:....:...:.  .|
Human    68 TPTEEGLKNSTQMSA------TYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIR 126

  Fly   131 YFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVAR---MGLEAGKSFDV 192
            :.|||.|:|:|:|.|..|..||:|:.|.||.:||||::..|...:..::.:   :..|.....|:
Human   127 FLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDM 191

  Fly   193 HDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREK 257
            .:::|..|:|.|...........:...| ||...::::..::.||...:|..:|.:|..:....:
Human   192 FEHISLMTLDSLQKCIFSFDSHCQERPS-EYIATILELSALVEKRSQHILQHMDFLYYLSHDGRR 255

  Fly   258 GDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKR 322
            ..|...::...|..|:::|:.....:.                         :||..: |....:
Human   256 FHRACRLVHDFTDAVIRERRRTLPTQG-------------------------IDDFFK-DKAKSK 294

  Fly   323 RLALLDAMVEMAKNPDIE-WNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQ 386
            .|..:|.:: ::|:.|.: .:::||..|.:|.||.|||||::|.|:.|..:..|.:.|.:...|.
Human   295 TLDFIDVLL-LSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEV 358

  Fly   387 KAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIV 451
            :.:..|...::..:.|..::.:|...:.|:|||:||.|.|:|....|:.|..| ..:|||.|.::
Human   359 QELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDG-RVIPKGITCLI 422

  Fly   452 LQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVR 516
            ....||..|.::|:|..:||..|.||....|...:|||||||||:|:|:.:||.::||:|:.::.
Human   423 DIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLL 487

  Fly   517 NYIVHSTDTEADFKLQADIILKLENG-------FNVSLE 548
            ::......||...||  ::|::.|.|       .||||:
Human   488 HFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEPLNVSLQ 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	124/473 (26%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	128/492 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920