Protein Alignment Cyp4g1 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 130/545 - (23%)
• Similarity: 225/545 - (41%)
• Gaps: 112/545 - (20%)

  Fly    31 LVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYLN------ 89
            ||.|.:.: ||.|...:.:.::.: .||.|..||.||           .||....|..|
Human    14 LVATSLVL-LYIYGTHSHKLFKKL-GIPGPTPLPFLG-----------TILFYLRGLWNFDRECN 65

  Fly    90 -KYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYF--------KPWFGDGLLISNG 145
             ||||....:.|...::.:.:|..|:.:|       ..|.|..|        ..:....|..:..
Human    66 EKYGEMWGLYEGQQPMLVIMDPDMIKTVL-------VKECYSVFTNQMPLGPMGFLKSALSFAED 123

  Fly   146 HHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEA--GKSFDVHDYMSQTTVDILLSTA 208
            ..|:..|.:::|.|.....|..||........:|..:..||  .||.::.|:....|:|::..|.
Human   124 EEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTL 188

  Fly   209 MGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLD---------SIYKF-TKLREKGDRMMN 263
            .||......|....:.            :.:|.|.:||         |::.| |.:.|    .:|
Human   189 FGVNLDSLNNPQDPFL------------KNMKKLLKLDFLDPFLLLISLFPFLTPVFE----ALN 237

  Fly   264 IILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLD 328
            |  |:..|.|....:|                 |....|:..|:|.          .|.|:....
Human   238 I--GLFPKDVTHFLKN-----------------SIERMKESRLKDK----------QKHRVDFFQ 273

  Fly   329 AMVEMAKNPDIE----WNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAI 389
            .|::...:.:.:    .::.:::.:...|:|..:||||....|.:..:..|.|:|.|:..|..|:
Human   274 QMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAV 338

  Fly   390 FGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQY 454
            ..:.  ...|:...::|:||:.|:.|||||:|.|..:.|....|::: :|.: :|||..|:|..|
Human   339 LPNK--APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI-NGVF-IPKGLAVMVPIY 399

  Fly   455 CVHRRPDIYPNPTKFDPDN-FLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNY 518
            .:|..|..:..|.||.|:: |..:...:...|.:|||.||||:|:|.::|:..:|:.:...::|:
Human   400 ALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNF 464

  Fly   519 IVHSTDTEADFK--LQADIILKLEN 541
                     .||  .:..|.|||:|
Human   465 ---------SFKPCKETQIPLKLDN 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	111/477 (23%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	113/479 (24%)