DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and Cyp4f14

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001191262.1	Gene:	Cyp4f14 / 64385	MGIID:	1927669	Length:	524	Species:	Mus musculus

Alignment Length:	552	Identity:	155/552 - (28%)
Similarity:	262/552 - (47%)	Gaps:	54/552 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SSSSTTVLGFSPMLT------TLVGT--LVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHV 71
            |..|.:.||..|.:.      .|:|.  ::|..|.:.:.. .|.||.:...|.||:...| ..||
Mouse     2 SQLSLSWLGLGPEVAFPWKTLLLLGASWILARILIQIYAA-YRNYRHLHGFPQPPKRNWL-MGHV 64

  Fly    72 AAGLSNAEILAVGLGYLNKYGETMKAWLGNVLLVFLTNPSDIE---LILSGHQHLTKAEEYRYFK 133
            .......:.|......:..|.:....|:|.::.|.....|||.   |..|....|.....|...|
Mouse    65 GMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYSILK 129

  Fly   134 PWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVA---RMGLEAGKSFDVHDY 195
            ||.|||||:|.|..|..||:|:.|.||.:|||.:|..|.|.:..:.|   |:..:.....|:.::
Mouse   130 PWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLISDGSARLDMFEH 194

  Fly   196 MSQTTVDILLSTAMGVKKLPEGN---KSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREK 257
            :|..|:|.|.......    :.|   ||.||..|::::..::.||..:.|..:|.:|..|....:
Mouse   195 VSLMTLDSLQKCVFSF----DSNCQEKSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPDGMR 255

  Fly   258 GDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKR 322
            ..:..|::...|..|:::|.....::.                         |||..::...:|
Mouse   256 FRKACNVVHEFTDAVIRERHRTLPDQG-------------------------LDDFLKSKAKSK- 294

  Fly   323 RLALLDAMVEMAKNPD-IEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQ 386
            .|..:|.:: ::|:.| .|.:::||..|.:|.||||||||::|.|:.|..:..|.:.|.:...|.
Mouse   295 TLDFIDVLL-LSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEV 358

  Fly   387 KAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIV 451
            :.:.......:..:.|..::.:|...|.|:|||:|||.:|:|....|:.|..| .|:|||...::
Mouse   359 QELLRGREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDG-RTIPKGIICLI 422

  Fly   452 LQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVR 516
            ..:.:|..|.::|:|..:||..|.||.:.:....:|||||||||:|:|:.:||.::||.|:..:.
Mouse   423 SIFGIHHNPSVWPDPEVYDPFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLL 487

  Fly   517 NYIVHSTDTEADFKLQADIILKLENGFNVSLE 548
            .:.:...|.|.  :.|.::||:.|.|..:.:|
Mouse   488 RFRLLPDDKEP--RRQPELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	135/469 (29%)
Cyp4f14	NP_001191262.1	p450	52..511	CDD:365848	141/493 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920