DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	519	Identity:	163/519 - (31%)
Similarity:	277/519 - (53%)	Gaps:	36/519 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AMALYEYWRRNSREYRMVANIPS-PPELPILGQAHVAAGLSNAEILAVGLGYLNKYGET--MKAW 98
            |...|:..:....:::.:..||. ....|.:|.|  ....||.:.....:||..::..:  :|.|
Zfish    23 AYITYQLLKSYLHKWKELKPIPGIGNTFPFIGNA--LQFKSNGDFFLQLVGYTTEFQNSPLLKIW 85

  Fly    99 LGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSI 163
            :|.:..:.|.:...:|.:|:...|:.||..|::..||.|.|||.|.|..||..|||:.||||.||
Zfish    86 IGPIPFLILFHAETVETVLNNPVHIDKAYAYQFLHPWLGTGLLTSTGDKWRRRRKMLTPTFHFSI 150

  Fly   164 LKSFVPTFVDHSKAVVARMGLEAGKS-FDVHDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAV 227
            |..|:....:.::.::.::..:|||. |:...:::...:||:..||||.:...:.|...||.:.|
Zfish   151 LTEFLEVMNEQAEVLIEKLEKQAGKGPFNCFSHITLCALDIICETAMGKRIYAQSNYDSEYVRTV 215

  Fly   228 VDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEIS 292
            ..|.|||.:||....|..|.:|.:.....:.:|.:.|:...|..|:.:|.|..     :.||..|
Zfish   216 YRMSDIITRRQRMPWYWPDFVYNYVGEGREHNRSLKILHSFTESVINERAEYL-----SYVESDS 275

  Fly   293 TPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEG 357
                                  |:|.|.::|.|.||.:::...........|||.:||:|.||||
Zfish   276 ----------------------ESDQGMRKRRAFLDMLLKTKDEDGKMLTHKDIQEEVDTFMFEG 318

  Fly   358 HDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPP 422
            ||||:|..::|:.::|.|.::|.|...|...:||::. |.....|..:::|||.||.|:|||:|.
Zfish   319 HDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVFGESE-RPVNTEDLKKLRYLECVIKESLRLFPS 382

  Fly   423 VPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSF 487
            ||..||.:..|.::  ..:.|||||.::|:.|.:||.|..:|:|.:|.|:.||||....||.|::
Zfish   383 VPFFARTICDDTQI--NGFKVPKGTNIVVITYALHRDPRFFPDPEEFRPERFLPENCVGRHPYAY 445

  Fly   488 IPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLENGFNVSLEKRQ 551
            ||||||.|:|:|:::|:::.||:|:.|:|.:.:.:.....:.:...:::|:.|.|..::||:|:
Zfish   446 IPFSAGLRNCIGQRFAIMEEKVILAYILRYFNIVACQKREELRPLGELVLRPEQGIWITLERRK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	154/463 (33%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	156/488 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020