DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	552	Identity:	148/552 - (26%)
Similarity:	251/552 - (45%)	Gaps:	68/552 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SSSTTVLGFSPML--TTLVGTLVAMA------LYEYWRRNSREYRMVANI----PSPPELPILGQ 68
            |..|.|.|...:|  .:|:|.|:.:.      |:..|        ::.::    |:||...:.|.
Mouse     7 SHITNVFGIFGLLQVVSLLGLLLLLLKSAQYYLHRQW--------LIKSLQQFPPAPPPQWLFGN 63

  Fly    69 AHVAAGLSNAEILAVGLGYLNKYGETMKAWL-GNVLLVFLTNPSDIELILSGHQHLTKAEEYRYF 132
            .     |.:.::..: |..:.|:..|...|| ||...|.:.:|..:::|| |.........|.:|
Mouse    64 T-----LKDQDLQQI-LLCVEKFPSTYVRWLWGNHARVVIYDPDYMKVIL-GRSDPKVVRSYSFF 121

  Fly   133 KPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMG--LEAGKSFDVHDY 195
            .||.|.|||:.||..|..||:|:.|.||..|||.:|...||....::.:..  ::.....:::..
Mouse   122 APWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVMLDKWEQLVDQDCPLEIYQD 186

  Fly   196 MSQTTVDILLSTA---MGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREK 257
            :|..|::.::..|   .|..:|.:...|..|.:||.|:..:|:.|.....::.::||..:.....
Mouse   187 ISLMTMETMMKCAFSYQGSVQLEDCRNSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSNGRS 251

  Fly   258 GDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKR 322
            ......|....|.:|::.||...|.|                 ::.|..|            .|:
Mouse   252 FYHACQIAHKHTERVIRMRKAQLQNE-----------------AELEKFR------------KKK 287

  Fly   323 RLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQK 387
            ||..||.::..........:::|:..|::|.|||||:||::|.|:....:..|.:.|.:...|.|
Mouse   288 RLDFLDILLFAQTEDGKSLSDEDVRAEMDTFMFEGHNTTASGISWIFYALATHPEHQQRCREEVK 352

  Fly   388 AIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVL 452
            :|.|:.  ...|.....:|.|....|.|.||||||:|..:|.|...:....| .::|||..|.:.
Mouse   353 SILGNG--TSVTLNHLDQMPYTTMCIKEALRLYPPIPGASRELSSPVTFPDG-CSLPKGFLVTLS 414

  Fly   453 QYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRN 517
            .|.:|..|.:.||...|||..|.|.  |.|..::|:|||||.|:|:|:::.|.:|||.::..:..
Mouse   415 FYGLHHNPRLRPNAEVFDPSRFAPG--APRQTHAFLPFSAGTRNCIGKQFTMNELKVAVALTLLR 477

  Fly   518 YIVHSTDTEADFKLQADIILKLENGFNVSLEK 549
            :.:....|.... |.:.|:||.:||..:..:|
Mouse   478 FELLPDPTRVPI-LVSKIVLKSKNGIYLHTKK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	130/465 (28%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	134/486 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920