Protein Alignment Cyp4g1 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 151/557 - (27%)
• Similarity: 265/557 - (47%)
• Gaps: 70/557 - (12%)

  Fly    18 STTVLGFSPM------LTTLVGTLVAMALYEYWRRNSREYRMVAN------IPSPPE----LPIL 66
            |.:.||..||      |..|||....:|....|     .|....|      .|.||:    |..|
Human     5 SLSSLGLWPMAASPWLLLLLVGASWLLARILAW-----TYTFYDNCCRLRCFPQPPKRNWFLGHL 64

  Fly    67 GQAHVA-AGLSNAEILAVGLGYLNKYGETMKAWLG---NVLLVFLTNPSDIELILSGHQHLTKAE 127
            |..|.: .||...:.||.      .:|:....|:|   .::.:|  :|:.|:.:|.....:...:
Human    65 GLIHSSEEGLLYTQSLAC------TFGDMCCWWVGPWHAIVRIF--HPTYIKPVLFAPAAIVPKD 121

  Fly   128 E--YRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGL---EAG 187
            :  |.:.|||.|||||:|.|..|..||:|:.|.||.:|||.::..|.:....:.|:..|   |..
Human   122 KVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGS 186

  Fly   188 KSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFT 252
            ...|:.:::|..|:|.|...........: .|..||..|::::..::.||..::|..:|.:|..|
Human   187 ARLDMFEHISLMTLDSLQKCVFSFDSHCQ-EKPSEYIAAILELSALVTKRHQQILLYIDFLYYLT 250

  Fly   253 KLREKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDEND 317
            ...::..|...::...|..|:::|:.....:.                         :||..:..
Human   251 PDGQRFRRACRLVHDFTDAVIQERRRTLPSQG-------------------------VDDFLQAK 290

  Fly   318 VGAKRRLALLDAMVEMAKNPD-IEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAK 381
            ..:| .|..:|.:: ::|:.| .:.:::||..|.:|.||||||||::|.|:.|..:..|.:.|.:
Human   291 AKSK-TLDFIDVLL-LSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQER 353

  Fly   382 VFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKG 446
            ...|.:.:..|...::..:.|..::.:|...|.|:|||:||||.::|....|:.|..| ..:|||
Human   354 CRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDG-RVIPKG 417

  Fly   447 TTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLL 511
            ...::..:..|..|.::|:|..:||..|.|:.:..|...:|||||||||:|:|:.:||.::||:|
Human   418 IICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482

  Fly   512 STIVRNYIVHSTDTEADFKLQADIILKLENGFNVSLE 548
            ...:..:.|....||.  :.:.:::|:.|.|..:.:|
Human   483 GLTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	126/461 (27%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	129/479 (27%)