DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	176/568 - (30%)
Similarity:	275/568 - (48%)	Gaps:	97/568 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYLNK 90
            |:|      |||......:||.    |::.....|..||::|.|| ..|.:.:|||.....:.::
  Fly    12 PLL------LVAYLELSTFRRR----RVLNKFNGPRGLPLMGNAH-QMGKNPSEILDTVFSWWHQ 65

  Fly    91 YG-ETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKM 154
            || :....|:|....|.:|:...:|.|||....:||::.|:...||.|.|||.|.|..|..||||
  Fly    66 YGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWHKHRKM 130

  Fly   155 IAPTFHQSILKSF-------VPTFVDHSKAVVARMGLEAGKSFDVHDYMSQTTVDILLSTAMGVK 212
            |.|.||.:||:.|       ...|:.|.|.|.|     ....||..:.....|:|::..|||||.
  Fly   131 ITPAFHFNILQDFHEVMNENSTKFIKHLKTVAA-----GDNIFDFQEQAHYLTLDVICDTAMGVS 190

  Fly   213 KLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRK 277
            .....|:|....||..|||..|:.|....|.|.:.:|:.........|.:..:...|::::..|
  Fly   191 INAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKR- 254

  Fly   278 ENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVE--MAKNPDIE 340
                      :|...:...||.|               .|...::::|.||.::.  :...|
  Fly   255 ----------IEAHKSGAVSTNA---------------GDEFTRKKMAFLDTLLSSTIDGRP--- 291

  Fly   341 WNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNML-RDCTFADTM 404
            .|.|::.:||:|.||||||||::|.|||:.::..|:|.|.|:|.||:.:.|::.| ||.||.:..
  Fly   292 LNSKELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEIS 356

  Fly   405 EMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTT----VIVLQYCVHRRPDIYPN 465
            :||||:..|.|..|:||.||.|.|..:.|..:...  .||||||    :::|.|    ...::.:
  Fly   357 QMKYLDLFIKEAQRVYPSVPFIGRFTEKDYVIDGD--LVPKGTTLNLGLVMLGY----NEKVFKD 415

  Fly   466 PTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNY-IVHSTD----- 524
            |.||.|:.|..|:...   :.::|||||||:|:|:|:|:|::|.::|.|:||: ::.:.|
  Fly   416 PHKFRPERFELEKPGP---FEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSK 477

  Fly   525 ----------TEADFK------------LQADIILKLENGFNVSLEKR 550
                      .:|:.|            |.|.:.||.|||..:.|::|
  Fly   478 DGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLKER 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	155/474 (33%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	156/477 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.070