DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and Cyp4ad1

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	156/531 - (29%)
Similarity:	242/531 - (45%)	Gaps:	86/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 IPSPPELPILGQAHVAAGLSNAEILAVGLGYLNKYGETMKAWLGNVLLVF------LTNPSDIEL 115
            ||.|...|.:|.. ...||..||.....|.|..||.     :.|...|||      |::|::|:.
  Fly    35 IPGPTPYPFVGNL-FQFGLKPAEYPKKVLQYCRKYD-----FQGFRSLVFLQYHMMLSDPAEIQN 93

  Fly   116 ILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVA 180
            |||....|.|...|.:.:||.|||||.|:|..|..|:|:.||.|.:|.::.::        .||.
  Fly    94 ILSSSSLLYKEHLYSFLRPWLGDGLLTSSGARWLKHQKLYAPAFERSAIEGYL--------RVVH 150

  Fly   181 RMG----------LEAGKSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIH 235
            |.|          .:..:.||..:.:::.|:||:...|.|........::.:...|:.|:||::.
  Fly   151 RTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENATGQDSSSLNGETSDLHGAIKDLCDVVQ 215

  Fly   236 KRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPA 300
            :|...::.|.|::::.|....|..|.::::....::::..|:.....|        :|.....|.
  Fly   216 ERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRIISQRRHQLAAE--------NTCQQGQPI 272

  Fly   301 SKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGS 365
            :|                      ..||.:: .||.......|::|::||:|.:|.|||..:|..
  Fly   273 NK----------------------PFLDVLL-TAKLDGKVLKEREIIEEVSTFIFTGHDPIAAAI 314

  Fly   366 SFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIAR-- 428
            ||.|..:..|.:||.|...||:.|||:|...:...|...:|.|||.:|.|||||||.||||||
  Fly   315 SFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTN 379

  Fly   429 RLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNF-LPERMANRHYYSFIPFSA 492
            |...|:....    |.|.||||:....:......:.:|..|.|:.| .|........:..:||||
  Fly   380 RNPIDINGTK----VAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSA 440

  Fly   493 GPRSCVGRKYAMLKLKVLLSTIVRNYIV-------------HSTD-----TEADFKLQADIILKL 539
            |||.|:..|:||.::|.|||.::|.:.:             ||.:     :|.|..|...:.||.
  Fly   441 GPRRCIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKS 505

  Fly   540 ENGFNVSLEKR 550
            |||..:.|.||
  Fly   506 ENGIQIRLRKR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	142/478 (30%)
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	142/482 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.070