DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	553	Identity:	166/553 - (30%)
Similarity:	280/553 - (50%)	Gaps:	84/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LVGTLVAMALYEYWRRNSREYRMVAN----------IPSPPELP-ILGQAHVAAGLSNAEILAVG 84
            :|..|:.:.|:.::|...|.:::.::          .|.||... :||  |::..|.|.:    |
Mouse    23 VVSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLG--HMSMYLPNEK----G 81

  Fly    85 LGYLNKYGETMK----AWLGNVL-LVFLTNPSDIELILSGHQHLTKAEE--YRYFKPWFGDGLLI 142
            |....|..:||.    ||:|..| |:.|.:|..|:.:|.....:...:|  |.:.|||.||||||
Mouse    82 LQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDGLLI 146

  Fly   143 SNGHHWRHHRKMIAPTFHQSILKSFVPTF-----VDHSKAVVARMGLEAGK--SFDVHDYMSQTT 200
            |.|:.|..||:::.|.||..|||.::..|     :.|:|   .|..|..|.  |||:.:::|..|
Mouse   147 SKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMHAK---WRRHLAEGSVTSFDMFEHISLMT 208

  Fly   201 VDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFT----KLREKGDRM 261
            :|.|...........:...| :|..:::::..::.:||.:|.:.||.:|..|    :.|:..|.:
Mouse   209 LDSLQKCVFSYNSDCQERMS-DYISSIIELSALVVRRQYRLHHYLDFMYYLTADGRRFRQACDTV 272

  Fly   262 MNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLAL 326
            .|    .|::|:::|::..:::.           |......|:|  ..||.||          .|
Mouse   273 HN----FTTEVIQERRQALRQQG-----------AEAWLKAKQG--KTLDFID----------VL 310

  Fly   327 LDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFG 391
            |.|..|..|    |.:::||..|.:|.|||||||||:|.|:||..:..:.:.|.|...|.:.:..
Mouse   311 LLAKDEEGK----ELSDEDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMK 371

  Fly   392 DNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCV 456
            ...|.:..:.|..::.:....|.|:||.:|||.||:||...|:||..| ..:|||...:|..|..
Mouse   372 GRELEELDWDDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPDG-RVIPKGIICLVSIYGT 435

  Fly   457 HRRPDIYP-----NPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLS-TIV 515
            |..|.::|     ||.:||||.  |::   |...:|:|||||||:|:|:.:||.:::|::: |::
Mouse   436 HHNPIVWPDSKVYNPYRFDPDT--PQQ---RSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLL 495

  Fly   516 RNYIVHSTDTEADFKLQADIILKLENGFNVSLE 548
            |..:  |.|.....:.:.::||:.|||..:::|
Mouse   496 RFRL--SVDRTHKVRRKPELILRTENGLWLNVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	153/484 (32%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	155/503 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920