DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g1 and Cyp4ae1

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	170/543 - (31%)
Similarity:	271/543 - (49%)	Gaps:	61/543 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGL 85
            ||..:.::|.||.:|..:||.|.      .:.:...:||...:|:||.|..........:.....
  Fly     4 VLLVALLVTRLVASLFRLALKEL------RHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFA 62

  Fly    86 GYLNKYGET-MKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWR 149
            .|:.::|.: |...||:|::| ...|..|:.:|.|...|.|...|...:.|.|||||:|.|..|.
  Fly    63 EYVKRFGRSFMGTVLGHVVMV-TAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWH 126

  Fly   150 HHRKMIAPTFHQSILKSFVPTFVDHSKAVVARM-GLEAGKS-FDVHDYMSQTTVDILLSTAMGVK 212
            ..||:|.||||.|||:.||..|...|..:|.|: .|..|.. .:::..:....:||:..|||||.
  Fly   127 TMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGVN 191

  Fly   213 KLPEGNKSFEYAQAVVDMCDIIHKRQVK------LLYRLDSIYKFTKLREKGDRMMNIILGMTSK 271
            ...:|..| |...||.|:.:|:..|.::      .|:||.....|.| ::.|   :..:...|:.
  Fly   192 VDAQGADS-EVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRK-QQAG---VICLHEFTNG 251

  Fly   272 VVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKN 336
            :::.|:       |.:..|.:....:.|.                        ||||.::....:
  Fly   252 IIEQRR-------RLLAREANQDKPTKPH------------------------ALLDTLLRATVD 285

  Fly   337 PDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFA 401
            .. ...:|.|.|||||.:|||||||::..||.|.::..|:.:|.|:|.|.:..:|.::.|....:
  Fly   286 GQ-PLTDKQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILS 349

  Fly   402 DTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNP 466
            |...:.||..|:.|:||||||:|.:||.|:.||.:..|  .:|.||.|:||.:.:.|...|:.:|
  Fly   350 DFATLPYLSCVVKESLRLYPPIPAVARCLEKDLVIDEG--YIPVGTNVVVLLWQLLRDEAIFTDP 412

  Fly   467 TKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNY--IVHSTDTEADF 529
            ..|.|:..|.|.......||:||||||||:|:|:|:|:|::|.:::.::|:|  :....|.|...
  Fly   413 LVFQPERHLGEEAPRLSPYSYIPFSAGPRNCIGQKFALLEMKTMVTKVIRHYQLLPMGADVEPSI 477

  Fly   530 KLQADIILKLENGFNVSLEKRQY 552
            |    |:|:.::|.||.|..|.|
  Fly   478 K----IVLRSKSGVNVGLRPRLY 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	149/468 (32%)
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	155/494 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.070