DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and Cyp4d2

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	173/533 - (32%)
Similarity:	289/533 - (54%)	Gaps:	49/533 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LVGTLVAMA-----LYEY-WRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYLN 89
            :||.|:.:|     |::: |||...     ..:|.|..||.||...:..||...:|:........
  Fly     4 VVGVLLLVAFATLLLWDFLWRRRGN-----GILPGPRPLPFLGNLLMYRGLDPEQIMDFVKKNQR 63

  Fly    90 KYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKM 154
            |||...:.|:.:.|.||.|:|.|||.:||..||:||...|:....|.|||||:|.|..|...||:
  Fly    64 KYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWHGRRKI 128

  Fly   155 IAPTFHQSILKSFVPTFVDHSKAVVARMGLEAG--KSFDVHDYMSQTTVDILLSTAMGVKKLPEG 217
            |.||||..||:.||..|...|..:|.::...|.  ...::...:..|.:||:..||||.|...:.
  Fly   129 ITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTKINAQK 193

  Fly   218 NKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLRE--KGDRMMNIILGMTSKVVKDRKENF 280
            |.:..|.|||.|:.:|:.||.:....|:|.|::.|:..|  :.|:.:.::...|..::::|:|..
  Fly   194 NPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRERRETL 258

  Fly   281 QEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKD 345
            ...|:          .:||            :.:.|.:|.|||:||||.:::...: ....:::|
  Fly   259 VNNSK----------ETTP------------EEEVNFLGQKRRMALLDVLLQSTID-GAPLSDED 300

  Fly   346 IMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLE 410
            |.:||:|.||||||||::..||.|..:..|.::|.::..|.:.:.|::.....|..|..|:|::|
  Fly   301 IREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFME 365

  Fly   411 RVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNF- 474
            .||.|:|||:||||:|.|....|::: .|.: :|.||...:..:.:.|.|:.:.:|.:|.|:.|
  Fly   366 NVIKESLRLHPPVPMIGRWFAEDVEI-RGKH-IPAGTNFTMGIFVLLRDPEYFESPDEFRPERFD 428

  Fly   475 --LPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIIL 537
              :|:    .|.|::||||||||:|:|:|:|||::|..:|.::|::.:.....|....:  :|:|
  Fly   429 ADVPQ----IHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSM--NIVL 487

  Fly   538 KLENGFNVSLEKR 550
            :..||.::.|:.|
  Fly   488 RSANGVHLGLKPR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	158/466 (34%)
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	163/493 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.070