DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and Cyp4d1

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	170/541 - (31%)
Similarity:	284/541 - (52%)	Gaps:	51/541 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LVGTLVAMALYE----YWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYLNKY 91
            ::|.::|.||:.    |..:..|...:::.:|.||.||::|..|...|....|::.....::..|
  Fly     4 VIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETY 68

  Fly    92 G--ETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKM 154
            .  :.:|.|||..|.|.:.||.|:|::|...:...||.||:..:||..:|||:|.|..|...||:
  Fly    69 SKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRKI 133

  Fly   155 IAPTFHQSILKSFVPTFVDHSKAVVARM---GLEAGKS-FDVHDYMSQTTVDILLSTAMGVKKLP 215
            |.|.||..||..||..|...|:.::..|   .|:.|.| |.::|:::..|:|.:..|||||....
  Fly   134 ITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWINLCTMDTICETAMGVSINA 198

  Fly   216 EGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKENF 280
            :.|...||.|||..:..::|||...:|||.|..|..|.|.....:.:|::...|.|::..|:|..
  Fly   199 QSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREEL 263

  Fly   281 QEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKD 345
            ..|                .|.:|...||.      ||||||::|.||.:::...: :...:..|
  Fly   264 IRE----------------GSSQESSNDDA------DVGAKRKMAFLDILLQSTVD-ERPLSNLD 305

  Fly   346 IMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLE 410
            |.:||:|.|||||||||:...|....:..|.:.|.|.|.|.:::.|::.....::....::.|::
  Fly   306 IREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVD 370

  Fly   411 RVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFL 475
            ..:.||||:||.|||:.|::..|.:: :|. .:|.||.:.:....:.||.:::..|..|.|:.|.
  Fly   371 LCVKETLRMYPSVPLLGRKVLEDCEI-NGK-LIPAGTNIGISPLYLGRREELFSEPNIFKPERFD 433

  Fly   476 PERMANR-HYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADF--------KL 531
            ....|.: :.|::||||||||:|:|:|:|||::|.:::.::|:|       |.||        .|
  Fly   434 VVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHY-------EVDFVGDSSEPPVL 491

  Fly   532 QADIILKLENGFNVSLEKRQY 552
            .|::||:.:......:.:|.|
  Fly   492 IAELILRTKEPLMFKVRERVY 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	154/466 (33%)
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	162/503 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	8	8.070