DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g1 and CYP4V2

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_997235.3	Gene:	CYP4V2 / 285440	HGNCID:	23198	Length:	525	Species:	Homo sapiens

Alignment Length:	528	Identity:	167/528 - (31%)
Similarity:	286/528 - (54%)	Gaps:	37/528 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TLVGTLVAMALYEYWRRNSREYRMVANIPSPPE-LPILGQAHVAAGLSNAEILAVGLGYLNKYGE 93
            :|.|..:.::|.:.....:|:::.:..||:... .|::|.| :.......|.....:.|..:|..
Human    23 SLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHA-LLMKPDGREFFQQIIEYTEEYRH 86

  Fly    94 --TMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIA 156
              .:|.|:|.|.:|.|.|..::|:||:..:.:.|:..|::.:||.|.|||.|.|:.||..|||:.
Human    87 MPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLT 151

  Fly   157 PTFHQSILKSFVPTFVDHSKAVVARMGLEAG-KSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKS 220
            ||||.:||:.|:....:.:..:|.::..... ::|:...|::...:||:..||||.....:.|..
Human   152 PTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDD 216

  Fly   221 FEYAQAVVDMCDIIHKRQVKLLYR-LDSIYKFTKLREKGDRMMNIILGMTSKVVKDR--KENFQE 282
            .||.:||..|.::|.:| :|:.:. ||..|...|...:..:.:.|:...|:.|:.:|  :.|..|
Human   217 SEYVRAVYRMSEMIFRR-IKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANE 280

  Fly   283 ESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIM 347
            :.|      .....|.|:..|                   |.|.||.::.:..:.....:.:||.
Human   281 DCR------GDGRGSAPSKNK-------------------RRAFLDLLLSVTDDEGNRLSHEDIR 320

  Fly   348 DEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERV 412
            :||:|.||||||||:|..:::|.::|.:.::|.||..|...:||.:. |..|..|..:::|||.|
Human   321 EEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSD-RPATVEDLKKLRYLECV 384

  Fly   413 ILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPE 477
            |.|||||:|.|||.||.:..|.::|.  |.|.|||..:::.|.:||.|..:|||.:|.|:.|.||
Human   385 IKETLRLFPSVPLFARSVSEDCEVAG--YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPE 447

  Fly   478 RMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLENG 542
            ....||.|:::|||||||:|:|:|:|:::.|.:||.|:|::.:.|.....:..|:..:||:..||
Human   448 NAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNG 512

  Fly   543 FNVSLEKR 550
            ..:.|::|
Human   513 IWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	154/466 (33%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	159/491 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.020