Protein Alignment Cyp4g1 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 167/528 - (31%)
• Similarity: 286/528 - (54%)
• Gaps: 37/528 - (7%)

  Fly    30 TLVGTLVAMALYEYWRRNSREYRMVANIPSPPE-LPILGQAHVAAGLSNAEILAVGLGYLNKYGE 93
            :|.|..:.::|.:.....:|:::.:..||:... .|::|.| :.......|.....:.|..:|..
Human    23 SLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHA-LLMKPDGREFFQQIIEYTEEYRH 86

  Fly    94 --TMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIA 156
              .:|.|:|.|.:|.|.|..::|:||:..:.:.|:..|::.:||.|.|||.|.|:.||..|||:.
Human    87 MPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLT 151

  Fly   157 PTFHQSILKSFVPTFVDHSKAVVARMGLEAG-KSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKS 220
            ||||.:||:.|:....:.:..:|.::..... ::|:...|::...:||:..||||.....:.|..
Human   152 PTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDD 216

  Fly   221 FEYAQAVVDMCDIIHKRQVKLLYR-LDSIYKFTKLREKGDRMMNIILGMTSKVVKDR--KENFQE 282
            .||.:||..|.::|.:| :|:.:. ||..|...|...:..:.:.|:...|:.|:.:|  :.|..|
Human   217 SEYVRAVYRMSEMIFRR-IKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANE 280

  Fly   283 ESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIM 347
            :.|      .....|.|:..|                   |.|.||.::.:..:.....:.:||.
Human   281 DCR------GDGRGSAPSKNK-------------------RRAFLDLLLSVTDDEGNRLSHEDIR 320

  Fly   348 DEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERV 412
            :||:|.||||||||:|..:::|.::|.:.::|.||..|...:||.:. |..|..|..:::|||.|
Human   321 EEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSD-RPATVEDLKKLRYLECV 384

  Fly   413 ILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPE 477
            |.|||||:|.|||.||.:..|.::|.  |.|.|||..:::.|.:||.|..:|||.:|.|:.|.||
Human   385 IKETLRLFPSVPLFARSVSEDCEVAG--YRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPE 447

  Fly   478 RMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLENG 542
            ....||.|:::|||||||:|:|:|:|:::.|.:||.|:|::.:.|.....:..|:..:||:..||
Human   448 NAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNG 512

  Fly   543 FNVSLEKR 550
            ..:.|::|
Human   513 IWIKLKRR 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	153/458 (33%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	155/467 (33%)