Protein Alignment Cyp4g1 and CYP4A22

DIOPT Version :10

• Sequence 1: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 157/564 - (27%)
• Similarity: 258/564 - (45%)
• Gaps: 71/564 - (12%)

  Fly     1 MAVEVVQETLQQAASSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVA--NIPSPPEL 63
            |:|.|:..:.:....|.   :|..:.:|..|:..:.|..||.:     |::.:.|  ..|.||..
Human     1 MSVSVLSPSRRLGGVSG---ILQVTSLLILLLLLIKAAQLYLH-----RQWLLKALQQFPCPPSH 57

  Fly    64 PILGQAHVAAGLSNAEILAVGLGYLNKYGETMKA-------WL-GNVLLVFLTNPSDIELILSGH 120
            .:.|  |:.....:.|        |.:..|.:|.       |: |..:.|.|.:|..:::|| |.
Human    58 WLFG--HIQEFQHDQE--------LQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVIL-GR 111

  Fly   121 QHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLE 185
            ........|::..|..|.|||:.||..|..||:|:.|.||..|||.:|....|..:.::.:....
Human   112 SDPKSHGSYKFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEEL 176

  Fly   186 AGKS--FDVHDYMSQTTVDILLSTAMGVK-KLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDS 247
            .|:.  .:|..::|..|:|.::.:|...: .:.....|..|.||:.|:..::........:..|:
Human   177 LGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDT 241

  Fly   248 IYKFTKLREKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDD 312
            ||..|.......|...:....|.:|::.||...|                     |||   :|:.
Human   242 IYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQ---------------------KEG---ELEK 282

  Fly   313 IDENDVGAKRRLALLDAMVEMAK--NPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIH 375
            |..     ||.|..||.:: :||  |..| .::||:..||:|.||||||||::|.|:.|..:..|
Human   283 IKR-----KRHLDFLDILL-LAKMENGSI-LSDKDLRAEVDTFMFEGHDTTASGISWILYALATH 340

  Fly   376 KDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGP 440
            ...|.:...|...:.||.  ...|:....:|.|....|.|.||||||||.|.|.|...:....|
Human   341 PKHQERCREEIHGLLGDG--ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDG- 402

  Fly   441 YTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAML 505
            .::|||..|::..|.:|..|.::||...|||..|.|.  :.:|.::|:|||.|.|:|:|:::||.
Human   403 RSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPG--SAQHSHAFLPFSGGSRNCIGKQFAMN 465

  Fly   506 KLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLENGFNVSLEK 549
            :|||..:..:..:.:....|.....: |.::||.:||.::.|.:
Human   466 QLKVARALTLLRFELLPDPTRIPIPM-ARLVLKSKNGIHLRLRR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	137/465 (29%)
CYP4A22	NP_001010969.2	CYP4B-like	72..505	CDD:410771	138/470 (29%)