DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	165/548 - (30%)
Similarity:	283/548 - (51%)	Gaps:	57/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPE-LPILGQAHVAAGLSNA 78
            ::|:.:|.|    .|.|:..|..:..|      :|:::.:..|||... .|::|.| :....:|.
  Rat    18 AASAVSVAG----ATVLLNILQMLVSY------ARKWQQMRPIPSVARAYPLVGHA-LFMKPNNT 71

  Fly    79 EILAVGLGYLNKYGE--TMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLL 141
            |.....:.|..::..  .:|.|:|.|.||.|....::|:||:..:.:.|:..|::.:||.|.|||
  Rat    72 EFFQQIIQYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFMYKFLQPWLGLGLL 136

  Fly   142 ISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAG-KSFDVHDYMSQTTVDILL 205
            .|.|..||..|||:.|:||.:||:.|:....:.:..:|.::..... ::|:....::...:||:.
  Rat   137 TSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVNQEAFNCFFPITLCALDIIC 201

  Fly   206 STAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTS 270
            .||||.....:.|...||.:.|..|.|:|::|.....:..|..|...|......:.:..:...|:
  Rat   202 ETAMGKNIGAQSNGDSEYVRTVYRMSDMIYRRMKMPWFWFDLWYLMFKEGRDHKKGLKSLHTFTN 266

  Fly   271 KVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKR--------RLALL 327
            .|:.:|                     ..|.|.|          ::.:||.|        |.|.|
  Rat   267 NVIAER---------------------VNARKAE----------QDCIGAGRGPLPSKTKRKAFL 300

  Fly   328 DAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGD 392
            |.::.:......:.:.:||.:||:|.||||||||:|..:::|.::|.:.::|.||..|...:||.
  Rat   301 DLLLSVTDEEGNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFGR 365

  Fly   393 NMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVH 457
            :. |..|..|..::|||:.||.||||::|.|||.||.|..|.::|.  |.:.|||..:::.|.:|
  Rat   366 SH-RPVTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVAG--YKISKGTEAVIIPYALH 427

  Fly   458 RRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHS 522
            |.|..:|:|.:|.|:.|.||....||.|:::|||||||:|:|:|:|:::.|.:|:.|:|.:.:.|
  Rat   428 RDPRYFPDPEEFQPERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILREFWIES 492

  Fly   523 TDTEADFKLQADIILKLENGFNVSLEKR 550
            .....:..|..|:||:..||..:.|::|
  Rat   493 NQKREELGLAGDLILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	147/471 (31%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	147/472 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020