DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and CYP4X1

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_828847.1	Gene:	CYP4X1 / 260293	HGNCID:	20244	Length:	509	Species:	Homo sapiens

Alignment Length:	532	Identity:	151/532 - (28%)
Similarity:	253/532 - (47%)	Gaps:	64/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYLNKYGETMK 96
            :|.|.|:.||   .|..|..|.:...|:||....||....... .|.|.|.   ..:.||.....
Human    24 LGLLQAIKLY---LRRQRLLRDLRPFPAPPTHWFLGHQKFIQD-DNMEKLE---EIIEKYPRAFP 81

  Fly    97 AWLGNVLLVF-LTNPSDIELILS----GHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIA 156
            .|:|.....| :.:|...:.:||    ..|:|.|     :..|..|.||...:|..|..||:::.
Human    82 FWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQK-----FSPPLLGKGLAALDGPKWFQHRRLLT 141

  Fly   157 PTFHQSILKSFVPTFVDHSKAVVARMGLEAGK--------SFDVHDYMSQTTVDILLSTAMGVKK 213
            |.||.:|||:::.... ||    .:|.|:..:        |.:|:::::..::||::..|...:.
Human   142 PGFHFNILKAYIEVMA-HS----VKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKET 201

  Fly   214 LPEGNKSFE-YAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRK 277
            ..:.|.:.: ||:|:.::..||..|...|||..|.|:|.:....:..::..::...|..::::||
Human   202 NCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERK 266

  Fly   278 ENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWN 342
            ::.|    |.|::.:||        |...:|.||             .:|.|..|...:    ::
Human   267 KSLQ----AGVKQDNTP--------KRKYQDFLD-------------IVLSAKDESGSS----FS 302

  Fly   343 EKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMK 407
            :.|:..||:|.:..||||.:|..|:.|..:.::.:.|.:...|.:.|.||.  ...|:....||.
Human   303 DIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDG--SSITWDQLGEMS 365

  Fly   408 YLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPD 472
            |....|.||.||.|.||.|:|.|...|....| .|:|.|.||::..:.:|..|.::.||..|||.
Human   366 YTTMCIKETCRLIPAVPSISRDLSKPLTFPDG-CTLPAGITVVLSIWGLHHNPAVWKNPKVFDPL 429

  Fly   473 NFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIIL 537
            .|..|....||.|:::|||||.|:|:|:::||::|||.::.|:.::.| :.|...........||
Human   430 RFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV-TPDPTRPLTFPNHFIL 493

  Fly   538 KLENGFNVSLEK 549
            |.:||..:.|:|
Human   494 KPKNGMYLHLKK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	134/473 (28%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	141/500 (28%)
CYP4X1	NP_828847.1	heme binding region	447..460		7/12 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920