DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g1 and erg11

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_592990.1	Gene:	erg11 / 2542599	PomBaseID:	SPAC13A11.02c	Length:	495	Species:	Schizosaccharomyces pombe

Alignment Length:	545	Identity:	129/545 - (23%)
Similarity:	206/545 - (37%)	Gaps:	135/545 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 MLTTLVGTLVAMALYEY--------WRRNSREYRMVANIPSPP----ELPILGQAHVAAGLSN-- 77
            |..:||..|:::||..|        ..|||:.         ||    .:|.:|.| ||.|:..
pombe     1 MAFSLVSILLSIALAWYVGYIINQLTSRNSKR---------PPIVFHWIPFVGSA-VAYGMDPYV 55

  Fly    78 --AEILAVGLGYLNKYGET---------MKAWLGNVLLVFLTNPSDIEL-ILSGHQHLTKAEEYR 130
              .|..|       |||:.         |.|:||.....||.|....:| ....:.|||
pombe    56 FFRECRA-------KYGDVFTFVCMGRKMTAFLGVQGNDFLFNGKLADLNAEEAYSHLT------ 107

  Fly   131 YFKPWFGDGLL--ISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARM-GLEAGKSFDV 192
              .|.||..::  |.| |.:..|:|.|......|..:|:||..::...|.::.. ....||. .|
pombe   108 --TPVFGKDVVYDIPN-HVFMEHKKFIKSGLGFSQFRSYVPLILNEMDAFLSTSPDFGPGKE-GV 168

  Fly   193 HDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDS-------IYK 250
            .|.:....| :.:.||....:..|..|.|:     ....|:.|.        ||.       ::.
pombe   169 ADLLKTMPV-MTIYTASRTLQGAEVRKGFD-----AGFADLYHD--------LDQGFSPVNFVFP 219

  Fly   251 FTKL--REKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDI 313
            :..|  ..:.||...|:.....|::|||        |:..|...|.:..|..|.|  .||. ..:
pombe   220 WLPLPRNRRRDRAHKIMQKTYLKIIKDR--------RSSTENPGTDMIWTLMSCK--YRDG-RPL 273

  Fly   314 DENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDI 378
            .|::: |...:|||.|                           |..|::|...:.|.::|...:|
pombe   274 KEHEI-AGMMIALLMA---------------------------GQHTSAATIVWVLALLGSKPEI 310

  Fly   379 QAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTV 443
            ...::.|||.:.|:|:  :..|....:|..|..||.|||||:||:....|::..||.:......:
pombe   311 IEMLWEEQKRVVGENL--ELKFDQYKDMPLLNYVIQETLRLHPPIHSHMRKVKRDLPVPGSKIVI 373

  Fly   444 PKGTTVIVLQYCVHRRPDIYPNPTKFDP----DNFLPERMANRHYYS-----------FIPFSAG 493
            |....::..........:.:.:.|.|||    |....:..|.:..|.           ::||.||
pombe   374 PANNYLLAAPGLTATEEEYFTHATDFDPKRWNDRVNEDENAEQIDYGYGLVTKGAASPYLPFGAG 438

  Fly   494 PRSCVGRKYAMLKLKVLLSTIVRNY 518
            ...|:|.::|.:.|..::|..|.:|
pombe   439 RHRCIGEQFAYMHLSTIISKFVHDY 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	118/504 (23%)
erg11	NP_592990.1	CypX	28..495	CDD:225035	122/518 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050