DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g1 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001094915.1	Gene:	Cyp4f17 / 208285	MGIID:	3646233	Length:	524	Species:	Mus musculus

Alignment Length:	542	Identity:	152/542 - (28%)
Similarity:	256/542 - (47%)	Gaps:	48/542 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LGFSP------MLTTLVGTLVAMALYEYWRRNSRE-YRMVANIPSPPELPILGQAHVAAGLSNAE 79
            ||..|      .|..|||..:.:|....|.....: |..:...|.||..... ..|::...:|.|
Mouse     9 LGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPSRHWF-WGHMSMVKNNEE 72

  Fly    80 ILAVGLGYLNKYGETMKAWLGNVL-LVFLTNPSDIELILSGHQHLTKAEE--YRYFKPWFGDGLL 141
            .|.:.....:::.:....|:|... ::.|.:|..|..||.....:...|.  |.:.|||.|||||
Mouse    73 GLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGPILQASAAVAPKEMIFYGFLKPWLGDGLL 137

  Fly   142 ISNGHHWRHHRKMIAPTFHQSILKSFVPTF-----VDHSKAVVARMGLEAGKSFDVHDYMSQTTV 201
            :|.|..|..||.::.|.||..|||.::..|     :.|:|  ..|:..:.....|:.:::|..|:
Mouse   138 VSAGEKWSRHRHLLTPAFHFDILKPYMKNFNKSVNIMHAK--WQRLTTKGTACLDMLEHISLMTL 200

  Fly   202 DILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIIL 266
            |.|.:.........:.:.| ||..|:.::..:|.||..:....||.:|..|....:..:..:::.
Mouse   201 DSLQNCVFSFDSNCQESPS-EYIAAIQELSSLIVKRHHQPFLYLDFLYYCTADGRRFRKACDLVH 264

  Fly   267 GMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMV 331
            ..|..|:::|:.....::   ::|.   :.|...||      .||.||          .||.|..
Mouse   265 NFTDAVIRERRRTLSSQN---LDEF---LKSKTKSK------TLDFID----------VLLLAKD 307

  Fly   332 EMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLR 396
            |..|    |.:::||..|.:|.||.|||||::..|:.|..:..|.:.|.:...|.:.:......:
Mouse   308 EHGK----ELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQ 368

  Fly   397 DCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPD 461
            :..:.|..::.:|...|.|:|||:|||.:|:|....|:.|..| ..:||||..::..:.||..|:
Mouse   369 EIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDVVLPDG-RVIPKGTDCVISIFGVHHNPE 432

  Fly   462 IYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTE 526
            ::|:|..:||..|.||....|...:|||||||||:|:|:.:||.::||.|:..:..:.|...|.|
Mouse   433 VWPDPEVYDPFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMREMKVALALTLLRFRVLPGDKE 497

  Fly   527 ADFKLQADIILKLENGFNVSLE 548
            .  :.:.::||:.|.|..:.:|
Mouse   498 P--RRKPELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	134/467 (29%)
Cyp4f17	NP_001094915.1	p450	52..515	CDD:365848	141/495 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920