Protein Alignment Cyp4g1 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 121/540 - (22%)
• Similarity: 213/540 - (39%)
• Gaps: 106/540 - (19%)

  Fly    10 LQQAASSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREY----------RMVANIPSPP--- 61
            |.||..|    ||| ..|.....|.|::|.|.......|..|          ::.|.:.|||
Human    12 LLQAGGS----VLG-QAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIF 71

  Fly    62 -ELPILGQAHVAAGLSNAEILAVGLGYLNKYGETMK-AWLGNVLLVFLTNPSDIELILSGHQHLT 124
             .:|.||.| :|.|.|..|.|.   ....|||.... ..:|......|.:.:...|..|.::.|.
Human    72 SPIPFLGHA-IAFGKSPIEFLE---NAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLN 132

  Fly   125 KAEEY-RYFKPWFGDGLLISNGHH-WRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAG 187
            ..:.| |...|.||.|:.....:. :...:||:....:.:..|..|......:|......| |:|
Human   133 AEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWG-ESG 196

  Fly   188 KSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFT 252
            :. :|.:.:|    ::::.||                    ..|  :|.::::           :
Human   197 EK-NVFEALS----ELIILTA--------------------SHC--LHGKEIR-----------S 223

  Fly   253 KLREKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTP--------------VASTPASKK 303
            :|.||           .:::..|....|...:..:...:..|              :......|:
Human   224 QLNEK-----------VAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKR 277

  Fly   304 EGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFA 368
            ...::.:|||.:         .||||..:..:    ...:.::...:..::..|..|:|..|::.
Human   278 RQSQEKIDDILQ---------TLLDATYKDGR----PLTDDEVAGMLIGLLLAGQHTSSTTSAWM 329

  Fly   369 LCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYD 433
            ...:...|.:|.|.:.|||.:.|:| |...|:....::..|:|.|.|||||.||: :|..|:...
Human   330 GFFLARDKTLQKKCYLEQKTVCGEN-LPPLTYDQLKDLNLLDRCIKETLRLRPPI-MIMMRMART 392

  Fly   434 LKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCV 498
            .:..:| ||:|.|..|.|......|..|.:.....|:||.:|.:..|:...::::||.||...|:
Human   393 PQTVAG-YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCI 456

  Fly   499 GRKYAMLKLKVLLSTIVRNY 518
            |..:|.:::|.:.||::|.|
Human   457 GENFAYVQIKTIWSTMLRLY 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	92/444 (21%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	94/449 (21%)