Protein Alignment Cyp4g1 and CYP19A1

DIOPT Version :10

• Sequence 1: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 133/578 - (23%)
• Similarity: 228/578 - (39%)
• Gaps: 134/578 - (23%)

  Fly     5 VVQETLQQAASSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQA 69
            :|.|.|.....:.::.|....|..|..|..|..:.|. .|     .|...::||.|.....:|..
Human     1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLL-VW-----NYEGTSSIPGPGYCMGIGPL 59

  Fly    70 HVAAGLSNAEILAVGLG----YLNK-YGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEY 129
                 :|:...|.:|:|    |.|: |||.|:.|:.          .:..||:|....:....::
Human    60 -----ISHGRFLWMGIGSACNYYNRVYGEFMRVWIS----------GEETLIISKSSSMFHIMKH 109

  Fly   130 RYFKPWFGD------------GLLISNGHH-WRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVAR 181
            .::...||.            |::.:|... |:..|    |.|.:::           |...:.|
Human   110 NHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTR----PFFMKAL-----------SGPGLVR 159

  Fly   182 MGLEAGKSFDVH-DYMSQTT-----VDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQ-- 238
            |.....:|...| |.:.:.|     ||:|  |.:....|...|..|  .:..:|...|:.|.|
Human   160 MVTVCAESLKTHLDRLEEVTNESGYVDVL--TLLRRVMLDTSNTLF--LRIPLDESAIVVKIQGY 220

  Fly   239 ----VKLLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKENFQ----EESRAIVEEISTPV 295
                ..||.:.|..:|.:.|.:|.:           |.|||.|:..:    |:.|.|
Human   221 FDAWQALLIKPDIFFKISWLYKKYE-----------KSVKDLKDAIEVLIAEKRRRI-------- 266

  Fly   296 ASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDT 360
                 |.:|.|.:.:|...|..:..||.                :...:::...:..::....||
Human   267 -----STEEKLEECMDFATELILAEKRG----------------DLTRENVNQCILEMLIAAPDT 310

  Fly   361 TSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPL 425
            .|....|.|.::..|.:::..:..|.:.:.|:   ||....|..::|.:|..|.|::|..|.|.|
Human   311 MSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE---RDIKIDDIQKLKVMENFIYESMRYQPVVDL 372

  Fly   426 IARR-LDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIP 489
            :.|: |:.|  :..| |.|.|||.:|:....:||. :.:|.|.:|..:||    ..|..|..|.|
Human   373 VMRKALEDD--VIDG-YPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENF----AKNVPYRYFQP 429

  Fly   490 FSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLENGFNVSL 547
            |..|||.|.|:..||:.:|.:|.|::|.:.|.:        ||...:..::...::||
Human   430 FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKT--------LQGQCVESIQKIHDLSL 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	109/482 (23%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	114/496 (23%)