Protein Alignment Cyp4g1 and CYP7A1

DIOPT Version :10

• Sequence 1: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_000771.2
• Gene: CYP7A1 / 1581
• HGNCID: 2651
• Length: 504
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 116/564 - (20%)
• Similarity: 195/564 - (34%)
• Gaps: 186/564 - (32%)

  Fly    27 MLTTLVGTLVAMALYEYW------RRNSREYRMVANIPSPP----ELPILGQAHVAAGLSNAEIL 81
            |.|:|:..:...|....|      ||.:.|         ||    .:|.||.| :..|.:..|.|
Human     2 MTTSLIWGIAIAACCCLWLILGIRRRQTGE---------PPLENGLIPYLGCA-LQFGANPLEFL 56

  Fly    82 AVGLGYLNKYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGH 146
            ...   ..|:|......|....:.|:|||      ||.|:.|...   :||
Human    57 RAN---QRKHGHVFTCKLMGKYVHFITNP------LSYHKVLCHG---KYF-------------- 95

  Fly   147 HW-RHHRKMIAPTF-HQSI-------LKSFVPTFVDHSKAVVARMGLEAGKSFDVHDYMSQTTVD 202
            .| :.|....|..| |:||       .::...||:               |:...|...|.|  :
Human    96 DWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFI---------------KTLQGHALNSLT--E 143

  Fly   203 ILLSTAMGVKKLPEGNKS------------------FEYAQAVVDMCDIIHK--RQVKLLYRLDS 247
            .::.....:.:.|..:.|                  ||.....:...|:..:  ::..:|..||:
Human   144 SMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDN 208

  Fly   248 IYKFTKLREKGDRMMNIILGMTSKVVKD------------RKENFQEESRAIVEEISTPVASTPA 300
            ..:|.|:      ...::.|:...:.:.            |.||.|:.     |.||..:
Human   209 FKQFDKV------FPALVAGLPIHMFRTAHNAREKLAESLRHENLQKR-----ESISELI----- 257

  Fly   301 SKKEGLRDDL---DDIDENDVGAKRRLALLDA------------MVEMAKNPDIEWNEKDIMDEV 350
            |.:..|.|.|   ||:::    ||..|.:|.|            :.:|.:||:.   .|...:||
Human   258 SLRMFLNDTLSTFDDLEK----AKTHLVVLWASQANTIPATFWSLFQMIRNPEA---MKAATEEV 315

  Fly   351 -NTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVIL 414
             .|:...|...:..|:...|..                             |:..::..|:.:|.
Human   316 KRTLENAGQKVSLEGNPICLSQ-----------------------------AELNDLPVLDSIIK 351

  Fly   415 ETLRL-YPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPER 478
            |:||| ...:.:...:.|:.|.|..|.|.:.|...:.:....:|..|:|||:|..|..|.:|.|.
Human   352 ESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDEN 416

  Fly   479 -----------MANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLL 511
                       :..::||  :||.:|...|.||.:|:.::|..|
Human   417 GKTKTTFYCNGLKLKYYY--MPFGSGATICPGRLFAIHEIKQFL 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	98/489 (20%)
CYP7A1	NP_000771.2	CYP7A1	55..497	CDD:410724	100/501 (20%)