DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and CYP4B1

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens

Alignment Length:	544	Identity:	145/544 - (26%)
Similarity:	250/544 - (45%)	Gaps:	66/544 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAE 79
            :|....||||..::..|:             |.....:.:...|.||...:.|.|        .|
Human    17 ASGLILVLGFLKLIHLLL-------------RRQTLAKAMDKFPGPPTHWLFGHA--------LE 60

  Fly    80 ILAVG-----LGYLNKYGETMKAWLGNVL-LVFLTNPSDIELILSGHQHLTKAEE-YRYFKPWFG 137
            |...|     :.:.:::......|.|..: .:.:..|...:.:.|...  .||.: |.:|..|.|
Human    61 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIG 123

  Fly   138 DGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEA--GKSFDVHDYMSQTT 200
            .|||:..|..|..|||::.|.||..:||.:|..|.:.::.::.:...:|  |||||:...:....
Human   124 RGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMA 188

  Fly   201 VDILLSTAMGVKKLPEG-NKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNI 264
            ::.|:....|......| ::...|..||.|:..::.:|.|...|..|.||..|....:..|...:
Human   189 LNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQV 253

  Fly   265 ILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDA 329
            ....|.:|:::||...|:|.               ..||              :..:|.|..||.
Human   254 AHDHTDQVIRERKAALQDEK---------------VRKK--------------IQNRRHLDFLDI 289

  Fly   330 MVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNM 394
            ::......||:.::.|:..||:|.||||||||::|.|:.|..|.::.:.|.:...|.:.|.||..
Human   290 LLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD 354

  Fly   395 LRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRR 459
            .  ..:.|..:|.||...|.|:.|||||||.:.|:|...:....| .::|.|:.:.:..|.:||.
Human   355 F--FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDG-RSLPAGSLISMHIYALHRN 416

  Fly   460 PDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTD 524
            ..::|:|..||...|..|..:.||.::|:|||||||:|:|:::||.::||:.:..:..:......
Human   417 SAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDP 481

  Fly   525 TEADFKLQADIILKLENGFNVSLE 548
            :....|: ..::|:.:|||::.|:
Human   482 SRLPIKM-PQLVLRSKNGFHLHLK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	132/469 (28%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	137/496 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920