DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g1 and CYP4A11

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_000769.2	Gene:	CYP4A11 / 1579	HGNCID:	2642	Length:	519	Species:	Homo sapiens

Alignment Length:	557	Identity:	161/557 - (28%)
Similarity:	257/557 - (46%)	Gaps:	75/557 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 STTVLGFSPMLTTLVGTL---------------VAMALYEYWRRNSREYRMVANIPSPPELPILG 67
            |.:||..|.:|..:.|.|               |.:.|:..|.     .:.:...|.||...:.|
Human     2 SVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWL-----LKALQQFPCPPSHWLFG 61

  Fly    68 QAHVAAGLSNAEILAVGLGYLNKYGETMKA----WL-GNVLLVFLTNPSDIELILSGHQHLTKAE 127
              |:.....:.|     |..:.|:.||..:    || |..:.|.|.:|..:::|| |........
Human    62 --HIQELQQDQE-----LQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVIL-GRSDPKSHG 118

  Fly   128 EYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAGKS--F 190
            .||:..||.|.|||:.||..|..||:|:.|.||..|||.:|....|..:.::.:.....|:.  .
Human   119 SYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPL 183

  Fly   191 DVHDYMSQTTVDILLSTAMGVK-KLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKL 254
            :|..::|..|:|.::..|...: .:.....|..|.||:.|:.:::..|.....::.|:||..|..
Human   184 EVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSA 248

  Fly   255 REKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVG 319
            .....|...:....|.:|::.||...|                     |||   :|:.|..
Human   249 GRWTHRACQLAHQHTDQVIQLRKAQLQ---------------------KEG---ELEKIKR---- 285

  Fly   320 AKRRLALLDAMVEMAK--NPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKV 382
             ||.|..||.:: :||  |..| .::||:..||:|.||||||||::|.|:.|..:..|...|.:.
Human   286 -KRHLDFLDILL-LAKMENGSI-LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERC 347

  Fly   383 FAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGT 447
            ..|..::.||.  ...|:....:|.|....|.|.||||||||.|.|.|...:....| .::|||.
Human   348 REEIHSLLGDG--ASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDG-RSLPKGI 409

  Fly   448 TVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLS 512
            .|::..|.:|..|.::|||..|||..|.|.  :.:|.::|:|||.|.|:|:|:::||.:|||..:
Human   410 MVLLSIYGLHHNPKVWPNPEVFDPFRFAPG--SAQHSHAFLPFSGGSRNCIGKQFAMNELKVATA 472

  Fly   513 TIVRNYIVHSTDTEADFKLQADIILKLENGFNVSLEK 549
            ..:..:.:....|.....: |.::||.:||.::.|.:
Human   473 LTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	144/469 (31%)
CYP4A11	NP_000769.2	p450	52..505	CDD:278495	150/497 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920