Protein Alignment Cyp4g1 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 127/559 - (22%)
• Similarity: 230/559 - (41%)
• Gaps: 112/559 - (20%)

  Fly    26 PMLTTLVGTLVAMA---LYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGY 87
            |.|......|:|::   ||.|..|....::.: .||.|..||:||           .:|:...|.
Human     5 PNLAVETWLLLAVSLVLLYLYGTRTHGLFKRL-GIPGPTPLPLLG-----------NVLSYRQGL 57

  Fly    88 -------LNKYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFK--------PWFG 137
                   ..|||:....:.|.:.::.:|:|..|..:|       ..|.|..|.        .:..
Human    58 WKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVL-------VKECYSVFTNRRSLGPVGFMK 115

  Fly   138 DGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEA--GKSFDVHDYMSQTT 200
            ..:.::....|:..|.:::|||....||...|....:...:|..:..||  ||...:.|.....:
Human   116 SAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180

  Fly   201 VDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNII 265
            :|::..|:.||.                  .|.::..|...   ::|..||.|........::||
Human   181 MDVITGTSFGVN------------------IDSLNNPQDPF---VESTKKFLKFGFLDPLFLSII 224

  Fly   266 L---------GMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAK 321
            |         .:...:......||..:             |....||..|.|.          .|
Human   225 LFPFLTPVFEALNVSLFPKDTINFLSK-------------SVNRMKKSRLNDK----------QK 266

  Fly   322 RRLALLDAMVEMAKNPDIEWNEKDIMD-----EVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAK 381
            .||..|..|::...:.:.| :.|.:.|     :....:|.|::|||:..||.|..:..|.|:|.|
Human   267 HRLDFLQLMIDSQNSKETE-SHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 330

  Fly   382 VFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKG 446
            :..|..|:..:.  ...|:...::|:||:.|:.|||||:|....:.|....|::: :|.: :|||
Human   331 LQKEIDAVLPNK--APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-NGVF-IPKG 391

  Fly   447 TTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLL 511
            :.|::..|.:|..|..:..|.:|.|:.| .::..:...|.:.||..|||:|:|.::|::.:|:.|
Human   392 SMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455

  Fly   512 STIVRNY---------IVHSTDTEADFKLQADIILKLEN 541
            ..:::|:         |....||:...:.:..|:||:::
Human   456 IRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDS 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	108/483 (22%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	108/480 (23%)