DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g1 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	540	Identity:	148/540 - (27%)
Similarity:	249/540 - (46%)	Gaps:	60/540 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGL 85
            :.||......|...||.....:::.|.....:.:.:.|..|...:.|. |    |.:.|:..: |
Mouse    15 ISGFFQWAFLLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWGH-H----LKDKELQQI-L 73

  Fly    86 GYLNKY-GETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWR 149
            .::.|: ...::...|:.:.|.|.:|..::::| |......:..|::|.||.|.|||:.||..|.
Mouse    74 IWVEKFPSACLQCLSGSNIRVLLYDPDYVKVVL-GRSDPKASGIYQFFAPWIGYGLLLLNGKKWF 137

  Fly   150 HHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAGKSFDVHDY-------MSQTTVDILLST 207
            .||:|:.|.||..|||.:|....|.     ..:.|:..:..|..|:       :|..|:|.::..
Mouse   138 QHRRMLTPAFHYDILKPYVKIMADS-----VNIMLDKWEKLDGQDHPLEIFHCVSLMTLDTVMKC 197

  Fly   208 A---MGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMT 269
            |   .|..:|.|.:|.  |.:||.|:.::...|.....|:.:.||..:...........|....|
Mouse   198 AFSYQGSVQLDENSKL--YTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIAHEHT 260

  Fly   270 SKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMA 334
            ..|:|.||...|.|     ||:.       .::|                 ||.|..||.::...
Mouse   261 DGVIKMRKSQLQNE-----EELQ-------KARK-----------------KRHLDFLDILLFAR 296

  Fly   335 KNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCT 399
            .......:::|:..||:|.||||||||::|.|:....:..|.:.|.:...|.::|.||.  ...|
Mouse   297 MEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGDG--TSVT 359

  Fly   400 FADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYP 464
            :....:|.|....|.|.|||||||..::|.|...:....| .::|||.|..:..|.:|..|..:|
Mouse   360 WDHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDG-RSIPKGITATISIYGLHHNPRFWP 423

  Fly   465 NPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADF 529
            ||..|||..|.|:  ::.|.::::|||.|.|:|:|:::||.:|||.::..:..:.:....|....
Mouse   424 NPKVFDPSRFAPD--SSHHSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPV 486

  Fly   530 KLQADIILKLENGFNVSLEK 549
            .: |.::||.:||.::.|:|
Mouse   487 PI-ARLVLKSKNGIHLCLKK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	134/470 (29%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	140/497 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920