DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and Cyp4a12b

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus

Alignment Length:	563	Identity:	154/563 - (27%)
Similarity:	263/563 - (46%)	Gaps:	86/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQETLQQAASSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAH 70
            :.|.||.|:..|          |..|:.....:.|:..|..:|.:     ..||||...:.|...
Mouse    15 ISEYLQVASVLS----------LLLLLFKTAQLYLHRQWLLSSTQ-----QFPSPPSHWLFGHKI 64

  Fly    71 VAAGLSNAEILAVGLGYLNKYGETMKAWL-GNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKP 134
                |.:.::..: |..:..:......|| |:.:.:.:.:|..::||| |.........||:..|
Mouse    65 ----LKDQDLQDI-LTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLIL-GRSDPKAHGSYRFLAP 123

  Fly   135 WFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEAGK--SFDVHDYMS 197
            |.|.|||:.:|..|..||:|:.|.||..|||.:.....|....::.:.....|:  :.::..:::
Mouse   124 WIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHIT 188

  Fly   198 QTTVDILLSTAM---GVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGD 259
            ..|:|.::..|.   |..:|....||  |.|||.|:.::...|...:.::.|.||:.:......:
Mouse   189 LMTLDTIMKCAFSHEGSVQLDRKYKS--YIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLAN 251

  Fly   260 RMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRL 324
            ....:....|.:|:|.|:...|:|                        ::|:.:.:     ||||
Mouse   252 SACQLAHDHTDQVIKSRRSQLQDE------------------------EELEKLKK-----KRRL 287

  Fly   325 ALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAI 389
            ..||.::..........::||:..||:|.||||||||::|.|:....:..:.:.|.:...|.:::
Mouse   288 DFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSL 352

  Fly   390 FGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQY 454
            .||.  ...|:.|..:|.|....|.|.||:|||||.::|.|...:....| .::|||..|::..|
Mouse   353 LGDG--ASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDG-RSLPKGIHVMLSFY 414

  Fly   455 CVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLS-TIVRNY 518
            .:|..|.::|||..|||..|.|.  ::||.:||:|||.|.|:|:|:::||.:|||.:: |::|
Mouse   415 GLHHNPTVWPNPEVFDPSRFAPG--SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLR-- 475

  Fly   519 IVHSTDTEADFKLQAD----------IILKLENGFNVSLEKRQ 551
                      |:|..|          |:||.:||.::.|:|.|
Mouse   476 ----------FELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	133/466 (29%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	135/482 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920