DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and CYP4F22

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_775754.2	Gene:	CYP4F22 / 126410	HGNCID:	26820	Length:	531	Species:	Homo sapiens

Alignment Length:	540	Identity:	157/540 - (29%)
Similarity:	264/540 - (48%)	Gaps:	61/540 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VGTLVAMALYEYWR------RNSREY----RMVANIPSPPELP-ILGQAHVAAGLSNAEILAVGL 85
            |.||:...|:..:|      |..|.:    |.:...|.||... :||  |:...|.|...|....
Human    24 VSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLG--HLGMYLPNEAGLQDEK 86

  Fly    86 GYLNKYGETMKAWLGNVL-LVFLTNPSDIELILSGHQHLTKAEE--YRYFKPWFGDGLLISNGHH 147
            ..|:.....:..|:|.|| |:.|.:|..|:.:|.....:...::  |.:.|||.|||||:|.|..
Human    87 KVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDK 151

  Fly   148 WRHHRKMIAPTFHQSILKSFVPTF---VDHSKAVVARMGLEAGKSFDVHDYMSQTTVDILLSTAM 209
            |..||:::.|.||..|||.::..|   .|...|....:...:..|.|:.:::|..|:|.|.....
Human   152 WSRHRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVF 216

  Fly   210 GVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVK 274
            ......: .|..:|..|::::..:..:||.:|.:.||.||..:....:..:..:::...|::|::
Human   217 SYNSNCQ-EKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQ 280

  Fly   275 DRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDI 339
            :|:...:::.           |......|:|  ..||.||          .||.|..|..|
Human   281 ERRRALRQQG-----------AEAWLKAKQG--KTLDFID----------VLLLARDEDGK---- 318

  Fly   340 EWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTM 404
            |.:::||..|.:|.|||||||||:|.|:.|..:..:.:.|.|...|.:.:.....|.:..:.|..
Human   319 ELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLT 383

  Fly   405 EMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYP----- 464
            ::.:....|.|:||.||||.|::|:...|:||..| ..:|||...:|..|..|..|.::|
Human   384 QLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDG-RIIPKGIICLVSIYGTHHNPTVWPDSKVY 447

  Fly   465 NPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLS-TIVRNYIVHSTDTEAD 528
            ||.:|||||  |::   |...:::|||||||:|:|:.:||.:|:|::: |::|..:  |.|....
Human   448 NPYRFDPDN--PQQ---RSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRL--SVDRTRK 505

  Fly   529 FKLQADIILKLENGFNVSLE 548
            .:.:.::||:.|||..:.:|
Human   506 VRRKPELILRTENGLWLKVE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	141/472 (30%)
CYP4F22	NP_775754.2	p450	60..524	CDD:278495	148/501 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920