DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	554	Identity:	149/554 - (26%)
Similarity:	257/554 - (46%)	Gaps:	64/554 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 STTVLGFSP------MLTTLVGTLVAMALYEYWR----RNSREYRMVANIPSPPELP-ILGQAHV 71
            |.:.||..|      :|..:||....:|....|.    .|.|..|.   .|.|.:.. .||  |:
Human     5 SLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRC---FPQPRKQNWFLG--HL 64

  Fly    72 AAGLSNAEILAVGLGYLNKYGETMKAWLGNVL-LVFLTNPSDIELILSGHQHLTKAE--EYRYFK 133
            .......|.|.|....:..|.:....|||.:. ::.|.:|..:..:::....:|..:  .|:..|
Human    65 GLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLK 129

  Fly   134 PWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTF-----VDHSKAVVARMGLEAGKSFDVH 193
            ||.|||||:|.|..|||||:::.|.||.:|||.::..|     :.|:|  ..|:.:|.....||.
Human   130 PWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAK--WQRLAMEGSTCLDVF 192

  Fly   194 DYMSQTTVDILLSTAMGVKKLPEGN---KSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLR 255
            :::|..|:|.|.......    :.|   |..||..|::::..::.||..:.....|.:|..|...
Human   193 EHISLMTLDSLQKCIFSF----DSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCG 253

  Fly   256 EKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGA 320
            .:..|...::...|..|:::|:.....:.                         :||..:....:
Human   254 RRFHRACRLVHDFTDAVIQERRRTLTSQG-------------------------VDDFLQAKAKS 293

  Fly   321 KRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAE 385
            | .|..:|.::........|.:::||..|.:|.||.|||||::|.|:.|..:..|.:.|.:...|
Human   294 K-TLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQE 357

  Fly   386 QKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVI 450
            .:.:..|...::..:.|..::.:|...:.|:|||:||:|..||....|:.|... ..:|||....
Human   358 VQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDS-RVIPKGNVCN 421

  Fly   451 VLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLS-TI 514
            :..:.:|..|.::|:|..:||..|.||....|...:|||||||||:|:|:|:||.::||:|: |:
Human   422 INIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTL 486

  Fly   515 VRNYIVHSTDTEADFKLQADIILKLENGFNVSLE 548
            :|..|:   ....:.:...:|:|:.|:|..:.:|
Human   487 LRFRIL---PDHREPRRTPEIVLRAEDGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	131/472 (28%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	132/489 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920