Protein Alignment Cyp4g1 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 121/516 - (23%)
• Similarity: 226/516 - (43%)
• Gaps: 85/516 - (16%)

  Fly    25 SPMLTTLVGTLVAMAL-----YEYWRRNSREYRMVANIPSPP-------ELPILGQAHVAAGLSN 77
            ||.| .|:|:.|.:|.     :.:..|:..|:     ||.||       .||...:.....|...
Human     2 SPGL-LLLGSAVLLAFGLCCTFVHRARSRYEH-----IPGPPRPSFLLGHLPCFWKKDEVGGRVL 60

  Fly    78 AEILAVGLGYLNKYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGL-- 140
            .::.   |.:..|||..::..:.:...|.:|:|..::..|...::...::.||..:..||:.|
Human    61 QDVF---LDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFG 122

  Fly   141 --LIS--NGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEA-GKS-FDVHDYMSQT 199
              |:|  |...|...|::|...|.:|.|.|.:.||.:.::.:|..:..:| |:: ..:.|.::.|
Human   123 QGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYT 187

  Fly   200 TVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNI 264
            .:|||...|.|::...........:|||..|.:.|...:       :::.||...:.|..|.:..
Human   188 AMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASR-------NTLAKFLPGKRKQLREVRE 245

  Fly   265 ILGMTSKVVKD----RKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLA 325
            .:....:|.:|    |:|..:..     ||:...:.:.....:||.:||
Human   246 SIRFLRQVGRDWVQRRREALKRG-----EEVPADILTQILKAEEGAQDD---------------- 289

  Fly   326 LLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIF 390
                              :.::|...|....||:|::...:|.:..:....:|.|::.||...:.
Human   290 ------------------EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI 336

  Fly   391 GDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYC 455
            |.....|  |.|...::||.:|:.|:||||||.....|.|:.: .|..| ..||..|.::...|.
Human   337 GSKRYLD--FEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDG-VRVPGNTPLLFSTYV 397

  Fly   456 VHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVR 516
            :.|....:.:|..|:||.|.|.  |.:..:::.|||.|.|||:|:::|.:::||:::.:::
Human   398 MGRMDTYFEDPLTFNPDRFGPG--APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	102/437 (23%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	105/451 (23%)