DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and Cyp4f15

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_598888.1	Gene:	Cyp4f15 / 106648	MGIID:	2146921	Length:	534	Species:	Mus musculus

Alignment Length:	555	Identity:	169/555 - (30%)
Similarity:	273/555 - (49%)	Gaps:	78/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SP-MLTTLVGT--LVAMAL---YEYWRRNSREYRMVANIPSPPE----LPILGQ-AHVAAGLSNA 78
            || :|..|:|.  |:|..|   |.::    |.|..:.:.|.||:    |..||. .....||...
Mouse    22 SPWLLLLLIGASWLLARVLTQTYIFY----RTYHHLCDFPQPPKWNWFLGHLGMITPTEHGLKEV 82

  Fly    79 EILAVGLGYLNKYGETMKAWLGNVL-LVFLTNPSDIELILSGHQHLTKAEE--YRYFKPWFGDGL 140
            ..|..      .|.:....|||.:: ::.|.:|..|..:|:....:...|.  |.:.|||.||||
Mouse    83 TNLVA------TYPQGFMTWLGPIIPIITLCHPDIIRSVLNASASVALKEVVFYSFLKPWLGDGL 141

  Fly   141 LISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVAR-MGLEAGKS--FDVHDYMSQTTVD 202
            |:|:|..|..||:|:.|.||.:|||.:|..|.|.:..:.|: ..|.:|.|  .||.:.:|..|:|
Mouse   142 LLSDGDKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQHLASGGSARLDVFENISLMTLD 206

  Fly   203 ILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILG 267
            .|...........:.|.| ||..|::::..::.||..:||..:||:|:.|....:..:..:::..
Mouse   207 SLQKCVFSFDSNCQENPS-EYISAILELSALVTKRYHQLLLHIDSLYQLTCSGRRFHKACHLVHS 270

  Fly   268 MTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLD--AM 330
            .|..|::||:.                   |..||.|      ||:    :.||.:...||  .:
Mouse   271 FTDAVIQDRRR-------------------TLPSKHE------DDV----LKAKAKSKTLDFIDV 306

  Fly   331 VEMAKNPD-IEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDN- 393
            :.::|:.| .|.:::||..|.:|.||||||||::|.|:.|..:..|.:.|.:...|.:.:..|.
Mouse   307 LLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQEVQELLRDRE 371

  Fly   394 ----------MLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTT 448
                      .|||    |..::.:|...|.|:|||:|||.:|:||...|:.|..| ..:|||..
Mouse   372 STEIECSCAVFLRD----DLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDG-RVIPKGVI 431

  Fly   449 VIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLST 513
            .|:..:..|..|.::|:|..:||..|.||.:.:|...:|||||||||:|:|:.:||.::||.|:.
Mouse   432 CIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPRNCIGQTFAMNEMKVALAL 496

  Fly   514 IVRNYIVHSTDTEADFKLQADIILKLENGFNVSLE 548
            .:..:.|...|.|.  :.:.::||:.|.|..:.:|
Mouse   497 TLLRFRVLPDDKEP--RRKPELILRAEGGLWLRVE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	150/484 (31%)
Cyp4f15	NP_598888.1	p450	57..526	CDD:278495	157/511 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920