DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g1 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	525	Identity:	168/525 - (32%)
Similarity:	282/525 - (53%)	Gaps:	31/525 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TLVGTLVAMALYEYWRRNSREYRMVANIPSPPE-LPILGQAHVAAGLSNAEILAVGLGYLNKYGE 93
            :|.|..:.::::......:|:::.:.:|||... .|::|.| :....:|||.....:.|..::..
Mouse    23 SLAGATILISIFPMLVSYARKWQQMRSIPSVARAYPLVGHA-LYMKPNNAEFFQQLIYYTEEFRH 86

  Fly    94 --TMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIA 156
              .:|.|:|.|.||.|....::|:||:..:.:.|:..|::.:||.|.|||.|.|..||..|||:.
Mouse    87 LPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFLYKFLQPWLGLGLLTSTGSKWRTRRKMLT 151

  Fly   157 PTFHQSILKSFVPTFVDHSKAVVARMGLEAG-KSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKS 220
            ||||.:||::|:....:.:..:|.::..... ::|:...|::...:||:..||||.....:.|..
Mouse   152 PTFHFTILENFLDVMNEQANILVNKLEKHVNQEAFNCFFYITLCALDIICETAMGKNIGAQSNND 216

  Fly   221 FEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKENFQEESR 285
            .||.:.|..|.|:|::|........|..|...|......|.:..:...|:.|:.:|    .:|.:
Mouse   217 SEYVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTFTNNVIAER----VKERK 277

  Fly   286 AIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEV 350
            |  ||..|.....|...|                 .:|.|.||.::.:........:::||.:||
Mouse   278 A--EEDWTGAGRGPIPSK-----------------NKRKAFLDLLLSVTDEEGNRLSQEDIREEV 323

  Fly   351 NTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILE 415
            :|.||||||||:|..:::|.::|.:.::|.||..|...:||.:. |..|..|..::|||:.||.|
Mouse   324 DTFMFEGHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGRSH-RPVTLEDLKKLKYLDCVIKE 387

  Fly   416 TLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMA 480
            |||::|.|||.||.|..|.::  |.|.|.|||..|::.|.:||.|..:|:|.:|.|:.|.||...
Mouse   388 TLRVFPSVPLFARSLSEDCEV--GGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRPERFFPENSQ 450

  Fly   481 NRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLENGFNV 545
            .||.|:::|||||||:|:|:|:|:::.|.:|:.|:|.:.|.|.....:..|..|:||:..||..:
Mouse   451 GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILRPNNGIWI 515

  Fly   546 SLEKR 550
            .|::|
Mouse   516 KLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	154/463 (33%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	162/492 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020