DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g1 and Cyp2c69

DIOPT Version :9

Sequence 1:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001097995.1	Gene:	Cyp2c69 / 100043108	MGIID:	3721049	Length:	491	Species:	Mus musculus

Alignment Length:	542	Identity:	120/542 - (22%)
Similarity:	199/542 - (36%)	Gaps:	146/542 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYLNKYGETM 95
            ||..|..|.|...||:.|....:.   |.|..|||:|..|:   :...:|......:...||...
Mouse     7 LVLCLSFMLLLSLWRQRSARRNLP---PGPTPLPIIGNYHL---IDMKDIGQCLTNFSKTYGPVF 65

  Fly    96 KAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWF-----GDGLLISNGHHWRHHRKMI 155
            ..:.|:..:|.|.....|:..|..|..:...   |...|:|     |.|:..|:|:.|:..|..
Mouse    66 TLYFGSQPIVVLHGYEAIKEALIDHGEVFSG---RGSFPFFDKVSKGKGIGFSHGNVWKATRVF- 126

  Fly   156 APTFHQSILKSFVPTFVDHSKAVVARMGLEAGKSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKS 220
                                                        ||:.|.:.|||.:.:.  ||.
Mouse   127 --------------------------------------------TVNTLRNLAMGKRTIE--NKV 145

  Fly   221 FEYAQAVVD-----------------------MCDIIHK-----RQVKLLYRLDSIYKFTK-LRE 256
            .|.||.::.                       :|.|:.:     :....|..:..:.:.|: |..
Mouse   146 QEEAQWLMKELKKTNGSPCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLSLIGKVNECTEILSS 210

  Fly   257 KGDRMMNII-------LGMTSKVVKDRK-------ENFQEESRAIVEEISTPVASTPASKKEGLR 307
            .|.::.|.:       .|..:|..|:..       |..:|...::  :::.|            |
Mouse   211 PGCQIFNAVPILIDYCPGRHNKFFKNHTWIKSYLLEKIKEHEESL--DVTNP------------R 261

  Fly   308 DDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNE---KDIMDEVNTIMFEGHDTTSAGSSFAL 369
            |.:|..                :::..::..||..|   :.:...|..::|.|.:|.|:...|||
Mouse   262 DFIDYF----------------LIQRRQDKGIEHMEYTIEHLATLVTDLVFGGTETLSSTMRFAL 310

  Fly   370 CMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYP--PVPLIARRLDY 432
            .::..|..|.|||..|...:.|.:  |.....|...|.|...::.|..|...  |..|: ..:..
Mouse   311 LLLMKHTHITAKVQEEIDNVIGRH--RSPCMQDRKHMPYTNAMVHEVQRYVDLGPTSLV-HEVTC 372

  Fly   433 DLKLASGPYTVPKGTTVIV-LQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRS 496
            |.|..:  |.:||||.|:. |...:|...: :|||..|||.:||.:....:....|:|||||.|.
Mouse   373 DTKFRN--YFIPKGTQVMTSLSSVLHDSTE-FPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRI 434

  Fly   497 CVGRKYAMLKLKVLLSTIVRNY 518
            |||...|.::|.:.|:||::|:
Mouse   435 CVGESLARMELFLFLTTILQNF 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	111/513 (22%)
Cyp2c69	NP_001097995.1	p450	30..487	CDD:278495	112/519 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010