DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ase and HAND1

DIOPT Version :9

Sequence 1:	NP_476694.1	Gene:	ase / 30985	FlyBaseID:	FBgn0000137	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_004812.1	Gene:	HAND1 / 9421	HGNCID:	4807	Length:	215	Species:	Homo sapiens

Alignment Length:	158	Identity:	43/158 - (27%)
Similarity:	58/158 - (36%)	Gaps:	56/158 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 PAKKCKTNKKLAVERP----------------PKAGTISHPHKSQSDQSFGTPGRKGL------P 156
            ||.:|..      |||                |..|  ..|..:.:..::|...|.|.      .
Human    31 PASRCHQ------ERPYFQSWLLSPADAAPDFPAGG--PPPAAAAAATAYGPDARPGQSPGRLEA 87

  Fly   157 LPQAVARRNA----RERNRVKQVNNGFALLREKIPEEVSEAFEAQGAGRGASKKLSKVETLRMAV 217
            |...:.||..    :||.|.:.:|:.||.|||.||..            .|..||||::|||:|.
Human    88 LGGRLGRRKGSGPKKERRRTESINSAFAELRECIPNV------------PADTKLSKIKTLRLAT 140

  Fly   218 EYIRSLEKLLGFDFPPLNSQGNSSGSGD 245
            .||..|..:|..|          :.|||
Human   141 SYIAYLMDVLAKD----------AQSGD 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ase	NP_476694.1	HLH	<172..224	CDD:278439	19/51 (37%)
HAND1	NP_004812.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..109		12/57 (21%)
		bHLH_TS_HAND1	94..153	CDD:381522	26/70 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..198
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900